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Similar Projects for

Project

PFI-TT: The Development of Flow-Through Sensors for the Detection of Bladder Cancer in Urine Samples

Funder: Directorate for Engineering

Funding period
USD 249 K
Funding amount
Abstract
The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project concerns the benefits of non-invasively detecting cancer in small samples of accessible bodily fluids (blood, urine, saliva). All biofluids are abundantly populated with small sacs that express specific indicators (biomarkers) when cancer is present. The ability to sample biofluids and detect these indicators is the basis of the "liquid biopsy" concept. A liquid biopsy for blood could be incorporated into routine laboratory tests and catch cancer in its earliest stages where intervention is most impactful. A liquid biopsy in urine could be used to replace highly invasive procedures currently used to routinely surveil for recurrence of bladder cancer. This PFI-TT project seeks to hasten the arrival of routine cancer screening through liquid biopsy by fundamentally advancing the way biosensors are used in these assays to make them faster and more sensitive. Educationally, the project will train two talented post-graduate scientists in the key elements of technical entrepreneurship. The project will also maintain several opportunities for undergraduates to conduct academic research including programs supporting under-represented groups and individuals unlikely to otherwise be exposed to research in college. The proposed project will advance the concept of the liquid biopsy by developing flow-through sensors that detect cancer biomarkers on extracellular vesicles (EVs) in urine. Current biomarker detection schemes require the analyte to diffuse from the sample to the sensing surface, resulting in slow and often incomplete, responses. The project will emphasis a different paradigm where the sensor is built on a highly permeable membrane and EVs carrying the biomarkers pass through the membrane where they are captured and revealed through enzyme-based detection. The team will develop and optimize the chemistries for capture of biomarkers and development of signal on the ultrathin silicon nitride membranes with precision slit-pores. The team will also develop mathematical models of flow through slit-pore membranes and the EV capture process. Finally, the team will compare our experiments and models to results with diffusion-limited sensors. This will directly test the hypothesis that the flow-through configuration enables more sensitive and faster responding devices that can improve detection of cancer in liquid biopsies. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

 
67
Projects
USD 58.8 M
Aggregated funding amount
USD 1.1 M
Average funding amount
Project list item
Identification and analysis of early prognostic markers of bladder cancer using generated nanobodies

Russian Science Foundation to Sergei Tillib

 
2020 - 2022
Project list item
[Biomarker screening of urothelial carcinoma using liquid biopsy] - Original in Japanese

Japan Society for the Promotion of Science to Yuichiro Suzuki

USD 38,300
2019 - 2022
Project list item
Novel Biomarkers for the Clinical Management of Bladder Cancer

National Cancer Institute to VINATA B LOKESHWAR

USD 902,622
2018 - 2023
Project list item
Circulating tumor DNA as a predictive biomarker in metastatic bladder cancer

Canadian Institutes of Health Research to Gillian Rae Vandekerkhove, Alexander William Wyatt

USD 79,759
2018 - 2021
Project list item
Circulating tumour DNA as a precision oncology tool for metastatic bladder cancer

Canadian Institutes of Health Research to Alexander William Wyatt

USD 110,675
2017 - 2020
Project list item
Non invasive Cell Based Liquid Biopsy Platform for Bladder Cancer

European Commission

USD 4,229,814
2017 - 2020
Project list item
Improved detection of bladder cancer recurrence using a biophysical biomarker

National Cancer Institute to MICHAEL D HENRY

USD 301,860
2017 - 2020
Project list item
IGF::OT::IGF GENETIC CYTOLOGY FOR SURVEILLANCE OF RECURRENT BLADDER CANCER

National Cancer Institute to ISAAC KINDE

USD 1,915,127
2017 - 2019
Project list item
Translation of a Clinical Molecular Diagnostic Assay for Bladder Cancer

National Cancer Institute to STEVE GOODISON

USD 1,823,874
2017 - 2022
Project list item
Development of personalized surgical algorithms for muscle-invasive bladder cancer patients

National Cancer Institute to PHILIP ABBOSH

USD 437,828
2017 - 2019
Project list item
Development of Novel Noninvasive Tests for Prognostic Predictions for Bladder Cancer

Congressionally Directed Medical Research Programs to Vinata B Lokeshwar

USD 608,000
2016 - 2017
Project list item
IGF::OT::IGF GENETIC CYTOLOGY FOR SURVEILLANCE OF RECURRENT BLADDER CANCER

National Cancer Institute to ISAAC KINDE

USD 299,824
2016 - 2017
Project list item
Monitoring Recurrent Bladder Cancer with Electro-Phage Biosensors

National Cancer Institute to GREGORY A. WEISS

USD 932,247
2016 - 2020
Project list item
Non-invasive genomic profiling of bladder cancer using urinary cfDNA

Innovate UK to Richard Palmer

USD 201,276
2016 - 2016
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