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Similar Projects for

Project

Sodium-glucose co-transporter 2 inhibitors and bladder cancer - a causal association or detection bias? An international multicenter cohort study.

Funder: Canadian Institutes of Health Research

Funding period
CAD 50 K
USD 37 K
Funding amount
Abstract
Type 2 diabetes is one of the fastest growing diseases in Canada, with approximately 60,000 new patients diagnosed each year. In recent years, there have been major advancements in the treatment of type 2 diabetes with the discovery of new drug classes, such as the sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 inhibitors have become increasingly popular, as they effectively lower blood sugar levels without the side effects of other antidiabetic drugs. However, these drugs have been associated with frequent urinary tract infections, and there are signals from trials that they may be associated with an increased risk of bladder cancer. To date, however, no study has been conducted in the real-world setting to assess this association. Thus, to address this gap in knowledge, I will conduct a multicenter cohort study among patients with type 2 diabetes using data sources from Canada, Europe and the Middle East. As a possible association may be explained by increased screening of the urinary tract, this international study will be specifically designed to differentiate between a possible biological effect and detection bias. Thus, this study will provide much needed information on the safety of SGLT2 inhibitors, and will be of value to regulatory agencies, physicians, and patients.

 
204
Projects
USD 123.9 M
Aggregated funding amount
USD 774 K
Average funding amount
Project list item
DNA adductome of human bladder from the tobacco exposome

National Institute of Environmental Health Sciences to ROBERT J. TURESKY

USD 467,974
2019 - 2023
Project list item
Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 203,510
2019 - 2021
Project list item
The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 45,016
2018 - 2021
Project list item
Novel 3D personalized bladder cancer model on demand: A new era for personalized medicine.

Canadian Institutes of Health Research to Alan I So, Claudia Itze Chavez-munoz

USD 141,091
2018 - 2020
Project list item
Novel recombinant BCG for immunotherapy of bladder cancer

National Cancer Institute to BORIS SHOR

USD 290,014
2018 - 2020
Project list item
Intra-operative MRI-guided Robotic System for Photothermal Therapy of Bladder Cancer

University Grants Committee to Kwok Ka Wai, TEOH Yuen Chun Jeremy, Vardhanabhuti Varut Vince, Wong Kenneth Kin Yip

USD 80,682
2018 - 2021
Project list item
Immune targeting of the V600E B-Raf neo-antigen in canine urothelial carcinoma

V Foundation for Cancer Research to Nicola J Mason

USD 91,573
2018 - 2020
Project list item
Exploiting candida and UPEC interactions with immune cells for the treatment of urinary tract infections and bladder cancer

Israel Science Foundation to Ofer Mandelboim, Nir Osherov, Francesca Levi-Schaffer, Gilad Bachrach, Ronen Ben-Ami

USD 2,028,658
2018 - 2021
Project list item
Dissection of Suppressive Axes Underlying Natural Killer Cell Dysfunction in Human Bladder Cancer

Congressionally Directed Medical Research Programs to Nina Bhardwaj

USD 1,584,753
2017 - 2018
Project list item
Dissection of Suppressive Axes Underlying Natural Killer Cell Dysfunction in Human Bladder Cancer

Congressionally Directed Medical Research Programs to John Sfakianos

USD 109,710
2017 - 2018
Project list item
Multiplex Functional Interrogation of Oncogenic Networks in Bladder Cancer

Congressionally Directed Medical Research Programs to John Lee

USD 633,600
2017 - 2018
Project list item
Immunologic and Microbial Correlates and Mechanisms of Complete Response to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer

Congressionally Directed Medical Research Programs to Philip Abbosh

USD 658,800
2017 - 2018
Project list item
Targeting the Regulation and Actions of Telomerase Reverse Transcriptase (TERT) in Bladder Cancer

Congressionally Directed Medical Research Programs to Dan Theodorescu

USD 1,482,998
2017 - 2018
Project list item
Dissecting the Interface Between ARID1A and mRNA Translation in Bladder Cancer

Congressionally Directed Medical Research Programs to Sujata Jana

USD 264,000
2017 - 2018
Project list item
INTRAVESICAL ONCOLYTIC THERAPY FOR BLADDER CANCER

National Cancer Institute to ROSA MARIA DIAZ, LUKKANA SUKSANPAISAN, BRADLEY C. LEIBOVICH

USD 1,990,950
2017 - 2020
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