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Similar Projects for

Project

Sodium-glucose co-transporter 2 inhibitors and bladder cancer - a causal association or detection bias? An international multicenter cohort study.

Funder: Canadian Institutes of Health Research

Funding period
CAD 50 K
USD 37 K
Funding amount
Abstract
Type 2 diabetes is one of the fastest growing diseases in Canada, with approximately 60,000 new patients diagnosed each year. In recent years, there have been major advancements in the treatment of type 2 diabetes with the discovery of new drug classes, such as the sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 inhibitors have become increasingly popular, as they effectively lower blood sugar levels without the side effects of other antidiabetic drugs. However, these drugs have been associated with frequent urinary tract infections, and there are signals from trials that they may be associated with an increased risk of bladder cancer. To date, however, no study has been conducted in the real-world setting to assess this association. Thus, to address this gap in knowledge, I will conduct a multicenter cohort study among patients with type 2 diabetes using data sources from Canada, Europe and the Middle East. As a possible association may be explained by increased screening of the urinary tract, this international study will be specifically designed to differentiate between a possible biological effect and detection bias. Thus, this study will provide much needed information on the safety of SGLT2 inhibitors, and will be of value to regulatory agencies, physicians, and patients.

 
85
Projects
USD 74.8 M
Aggregated funding amount
USD 997 K
Average funding amount
Project list item
Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 203,510
2019 - 2021
Project list item
The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 45,016
2018 - 2021
Project list item
Novel 3D personalized bladder cancer model on demand: A new era for personalized medicine.

Canadian Institutes of Health Research to Alan I So, Claudia Itze Chavez-munoz

USD 141,091
2018 - 2020
Project list item
Immune targeting of the V600E B-Raf neo-antigen in canine urothelial carcinoma

V Foundation for Cancer Research to Nicola J Mason

USD 91,573
2018 - 2020
Project list item
CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

Patient-Centered Outcomes Research Institute to John Gore

USD 8,500,000
2018 - 2022
Project list item
INTRAVESICAL ONCOLYTIC THERAPY FOR BLADDER CANCER

National Cancer Institute to ROSA MARIA DIAZ, BRADLEY C. LEIBOVICH, LUKKANA SUKSANPAISAN

USD 1,081,593
2017 - 2020
Project list item
Urothelial Stem Cells

National Institute of Diabetes and Digestive and Kidney Diseases to TUNG-TIEN SUN

USD 1,378,300
2017 - 2021
Project list item
Investigating the Role of the Tumor MicroEnvironment in Resistance of Urothelial Carcinoma of the Bladder to FGFR3 Inhibition

National Cancer Institute to CHERYL CLAUNCH-RABE

USD 148,584
2017 - 2021
Project list item
Cellular and molecular mechanisms of obstruction induced bladder dysfunction

São Paulo Research Foundation to Cristiano Mendes Gomes

 
2017 - 2019
Project list item
Development of Novel Noninvasive Tests for Prognostic Predictions for Bladder Cancer

Congressionally Directed Medical Research Programs to Vinata B Lokeshwar

USD 608,000
2016 - 2017
Project list item
Vascularization of Bioengineered Bladder Wall in a Large-Animal Model

Congressionally Directed Medical Research Programs to Eric Kurzrock

USD 785,000
2016 - 2017
Project list item
Sh3gl2 and chemosensitivity of bladder cancer

National Cancer Institute to ROSALYN M ADAM

USD 492,035
2016 - 2019
Project list item
Monitoring Recurrent Bladder Cancer with Electro-Phage Biosensors

National Cancer Institute to GREGORY A. WEISS

USD 932,247
2016 - 2019
Project list item
MULTIPLEXED PROTEIN BIOMARKER-BASED ASSAY FOR THE DETECTION OF BLADDER CANCER

National Cancer Institute to CHARLES J ROSSER

USD 2,568,621
2016 - 2021
Project list item
Notch in bladder cancer: oncogene and tumour suppressor

Canadian Cancer Society to Peter Black, Yuzhuo Wang, Mads Daugaard, Colin Collins

USD 758,595
2016 - 2020
Project list item
Metabolic traits, tobacco smoking, and gene loci, in relation to risk and prognosis of cancer of the prostate and urinary bladder

Swedish Research Council to Tanja Stocks, Pär Stattin, Marju Orho-Melander

USD 244,205
2016 - 2018
Project list item
Dissecting the Role of APOBEC3 Mutagenic Proteins as Drivers of Genomic Instability and Chemotherapy Resistance in Urothelial Carcinoma

Congressionally Directed Medical Research Programs to Bishoy M Faltas

USD 610,199
2015 - 2016
Project list item
Precision Medicine in Platinum-Treated Lethal Bladder Cancer

Congressionally Directed Medical Research Programs to Jonathan Rosenberg

USD 788,605
2015 - 2016
Project list item
Precision Medicine in Platinum-Treated Lethal Bladder Cancer

Congressionally Directed Medical Research Programs to David Mcconkey

USD 411,266
2015 - 2016
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