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Project

Biomarker-Based Tools for Treatment Response Decision Support of Bladder Cancer

Funder: National Cancer Institute

Funding period
USD 1.3 M
Funding amount
Abstract
PROJECT SUMMARY / ABSTRACT Bladder cancer is a common type of cancer that can cause substantial morbidity and mortality among both men and women. Bladder cancer causes over 16,870 deaths per year in the United States with 79,030 new bladder cancer cases diagnosed in 2017. A reliable assessment of the response to neoadjuvant therapy at an early stage is vital for identifying tumors that do not respond and allowing the patient a chance of alternative treatment. We have successfully developed a computer decision support system (CDSS-T) for monitoring of bladder cancer treatment response. A quantitative image analysis tool for bladder cancer (QIBC) that quantifies the bladder gross tumor volume (GTV) and image characteristics is an important component of CDSS-T. Advanced machine learning techniques are used to merge the GTV and radiomic biomarkers into an effective predictive model. The goal of this project is to validate the effectiveness of CDSS-T as an aid to the radiologists and the oncologists in assessment of bladder cancer change as a result of treatment through pilot clinical trials. We will (1) perform a preparatory clinical trial with the clinicians at UM, which will simulate the real prospective clinical trial with high quality retrospective data, (2) deploy the QIBC and CDSS-T tools at the three collaborating clinical sites, (3) use the QIBC and CDSS-T tools at the different clinical sites in the prospective pilot clinical trial (standard clinical workflow) utilizing the decision support in parallel to the standard clinical patient care, and (4) analyze the impact of the QIBC and CDSS-T tools on the clinicians' performance in the pilot clinical trial and assess the potential impact on clinical outcome. We hypothesize that this innovative approach can improve clinicians' accuracy, consistency and efficiency in bladder GTV estimation and assessment of treatment response. To test these hypotheses, we will perform the following specific tasks: (1) to evaluate the performance of the QIBC and CDSS-T tools on cases not previously used, new to the system, for both the prediction accuracy and the automatic standalone functionality, refine and optimize the design of the user interface based on clinicians' feedback after their hands-on experience with the system to ensure its practicality and robustness, familiarize clinicians with the performance of the CDSS-T tools and the interpretation of the CDSS-T outputs as a part of user training for the prospective pilot clinical trial, (2) to optimize the QIBC and CDSS-T tools for the clinical workflow at the different clinical sites based on the site clinicians' feedback in order to operate efficiently and in a standalone mode by clinicians, (3) to record the clinicians' predicted outcomes without and with the use of the tools during the pilot clinical trials, estimate the accuracy of assessing response to neoadjuvant chemotherapy in the current clinical treatment paradigm by comparing the estimated response to the histopathologically determined response after radical cystectomy, and (4) to statistically analyze the impact of the QIBC and CDSS-T tools on the performance of the clinicians in the pilot clinical trial and statistically assess the potential impact on clinical outcome.

 
47
Projects
USD 28.7 M
Aggregated funding amount
USD 797 K
Average funding amount
Project list item
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer

National Cancer Institute to NINA BHARDWAJ, JUN ZHU, MATTHEW GALSKY

USD 703,400
2020 - 2025
Project list item
Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder - (ADAPT-BLADDER)

National Cancer Institute to NOAH M HAHN

USD 1,313,632
2019 - 2024
Project list item
Immunologic and Microbial Correlates and Mechanisms of Complete Response to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer

Congressionally Directed Medical Research Programs to Philip Abbosh

USD 658,800
2017 - 2018
Project list item
Studying the Effect of PPARG Pathway Modulation on Tumor Immune Microenvironment in Muscle Invasive Bladder Cancer

Congressionally Directed Medical Research Programs to Shruti D Shah

USD 262,050
2017 - 2018
Project list item
Development of Classifiers for Novel Bladder Cancer Subtypes

Congressionally Directed Medical Research Programs to Woonyoung Choi

USD 856,134
2017 - 2018
Project list item
Development of Classifiers for Novel Bladder Cancer Subtypes

Congressionally Directed Medical Research Programs to Seungchan Kim

USD 706,947
2017 - 2018
Project list item
INTRAVESICAL ONCOLYTIC THERAPY FOR BLADDER CANCER

National Cancer Institute to ROSA MARIA DIAZ, LUKKANA SUKSANPAISAN, BRADLEY C. LEIBOVICH

USD 1,990,950
2017 - 2021
Project list item
Proteogenomic characterization of muscle invasive bladder cancer to identify mechanisms of resistance and targets for therapy

Bladder Cancer Advocacy Network to Seth P. Lerner, Susan Hilsenbeck, Matthew James Ellis, Keith Syson Chan, Jonathan Michael Levitt, Sung Yun Jung, Anna Malovannaya, Bing Zhang

USD 300,000
2017 - 2020
Project list item
Development of personalized surgical algorithms for muscle-invasive bladder cancer patients

National Cancer Institute to PHILIP ABBOSH

USD 437,828
2017 - 2019
Project list item
Development of Novel Noninvasive Tests for Prognostic Predictions for Bladder Cancer

Congressionally Directed Medical Research Programs to Vinata B Lokeshwar

USD 608,000
2016 - 2017
Project list item
Regulation of ATDC by TP63 and its role in bladder cancer

National Cancer Institute to PHILLIP L PALMBOS

USD 699,840
2016 - 2021
Project list item
Bladder Fiducial Markers and Diffusion-MRI to Optimize Bladder Chemo-Radiotherapy

National Cancer Institute to MAURICE MARCEL GARCIA

USD 1,574,130
2016 - 2023
Project list item
Precision Medicine in Platinum-Treated Lethal Bladder Cancer

Congressionally Directed Medical Research Programs to Eliezer M Van allen

USD 346,210
2015 - 2016
Project list item
Precision Medicine in Platinum-Treated Lethal Bladder Cancer

Congressionally Directed Medical Research Programs to Jonathan Rosenberg

USD 788,605
2015 - 2016
Project list item
Precision Medicine in Platinum-Treated Lethal Bladder Cancer

Congressionally Directed Medical Research Programs to David Mcconkey

USD 411,266
2015 - 2016
Project list item
Synergistic Immuno-Photo-Nanotherapy for Bladder Cancer

Congressionally Directed Medical Research Programs to Brant A. Inman

USD 624,398
2015 - 2016
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