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New zebrafish-based methods for prediction of cisplatin response in bladder cancer


Funding period
SEK 300 K
USD 34 K
Funding amount
Purpose and goal:
Urinary bladder cancer patients whose cancer has invaded the muscle layer around the bladder is treated with cisplatin combination drugs prior to operation. Many patients, however, do not respond to these drugs and these patients have reduced survival compared to responders or patients operated immediately after diagnosis. The goal of this Project is to develop a new method for identifying cisplatin non-responders immediately after diagnosis, which can then proceed directly to surgery instead of going through a period of ineffective treatment.

Expected results and effects:
We expect to successfully develop bladder tissue biopsy treatment and implantation methods in zebrafish embryos and in this environment evaluate cisplatin efficacy. The project is designed to evaluate 1) the proportion of patients in which we successfully implant tumor biopsies in zebrafish, 2) which effect of cisplatin observed in the zebrafish models correspond to a clinically meaningful effect in the patients and 3) the proportion of patients in which we correctly predict cisplatin response using the zebrafish model.

Approach and implementation:
Through our Clinical collaborators we expect to recruit 40 urinary bladder cancer patients from Swedish Urology clinics. We will recieve fresh tumor biopsies from these patients during the so-called TUR-B procedure and these biopsies are then pre-treated, labeled and implanted in zebrafish embryos. The tumor baring fish are then treated with two different cisplatin-containing combination drugs (GC or MVAC), alternatively only vehicle (control group), tumor growth or reduction is meassured during a three day treatment period and compared with patient responses

USD 165.3 M
Aggregated funding amount
USD 610 K
Average funding amount
Project list item
Bladder cancer chemotherapy potentiation with a multiprong arachidonic acid pathway modulator

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Investigating underlying molecular mechanisms of epigenetic therapies in muscle-invasive bladder cancer

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Targeting FGF in Bladder cancer after Neoadjuvant Immunotherapy and Surgery

American Association For Cancer Research to Joshua James Meeks

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Biomarker-Based Tools for Treatment Response Decision Support of Bladder Cancer


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Refined phenotyping and personalized targeting of muscle-invasive bladder cancer

Swiss National Science Foundation to Roland Seiler, Kiu Yan Charlotte Ng, Eugenio Zoni, Marianna Kruithof-de Julio, Martina Minoli, Franziska Singer, Federico La Manna, Vera Genitsch

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Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 203,510
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Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder - (ADAPT-BLADDER)

National Cancer Institute to NOAH M HAHN

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2019 - 2024
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Development of an automated method to capture bladder cancer recurrence and progression for epidemiologic research

National Cancer Institute to KIM N DANFORTH

USD 172,270
2019 - 2021
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Defining the impact of intra-tumoral morphologic, immune and mutational heterogeneity in urothelial carcinoma

National Cancer Institute to HIKMAT AL-AHMADIE

USD 410,835
2019 - 2024
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A revolutionary shape memory alloy-based disposable device for bladder cancer removal

European Commission

USD 57,207
2019 - 2019
Project list item
Clonal evolution and molecular stratification of urothelial carcinoma in situ of the urinary bladder

German Research Foundation to Stefan Garczyk, Nadine Gaisa

2019 -
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The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 45,016
2018 - 2021
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A co-clinical trial of chemotherapy response in bladder cancer using patient-derived tumor organoids

V Foundation for Cancer Research to Michael M Shen

USD 600,000
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Modulation of regulatory T cells in the bladder tumor environment by anti-PD-L1 immunotherapy

Bladder Cancer Advocacy Network to David Yoonsuk Oh, Lawrence Fong

USD 50,000
2018 - 2019
Project list item
Novel 3D personalized bladder cancer model on demand: A new era for personalized medicine.

Canadian Institutes of Health Research to Alan I So, Claudia Itze Chavez-munoz

USD 141,091
2018 - 2020
Project list item
Identifying DNA Biomarkers of Bacillus Calmette-Guerin (BCG) Resistance in Non-Muscle-Invasive Bladder Cancer

Canadian Institutes of Health Research to Jack Victor Warren Bacon, Alexander William Wyatt

USD 847
2018 - 2019
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Elucidating immunotherapy resistance mechanisms in non-T cell-inflamed bladder cancer

National Cancer Institute to RANDY F. SWEIS

USD 425,338
2018 - 2022
Project list item
Novel recombinant BCG for immunotherapy of bladder cancer

National Cancer Institute to BORIS SHOR

USD 290,014
2018 - 2020
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