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Similar Projects for

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[Clinicopathological and molecular analyses of precursor lesions of urothelial carcinoma]

Original in Japanese: Clinicopathological and molecular analyses of precursor lesions of urothelial carcinoma

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.3 M
USD 39 K
Funding amount
Abstract
[The purpose of this study is to analyze "flat urinary epithelium showing mild atypia that cannot be judged as cancer", that is, atypical urothelium, hyperplasia or dysplasia, etc. in the surrounding mucosa of urothelial cancer. , Based on the molecular pathological mechanism centered on MTOC (microtubule organizing center) involved in the formation of structural and cellular atypia in malignant tumors, which we clarified in the past studies, the early development of bladder urothelial carcinoma. To analyze the molecular mechanism of genetic abnormalities and formation of cell atypia in. Furthermore, based on molecular pathological mechanisms and genetic abnormalities, we will define histopathological diagnostic criteria for early lesions of urothelial cancer and clarify clinicopathologic features.]
Original in Japanese
本研究の目的は、尿路上皮癌の周囲粘膜における“癌とは判断できない程度の軽度異型を示す平坦状尿路上皮”、すなわち異型尿路上皮、過形成あるいは異形成等を解析の対象とし、我々が過去の研究で明らかにしてきた悪性腫瘍における構造異型や細胞異型の形成に関わるMTOC (microtubule organizing center)を中心とした分子病理学的機構を基に、膀胱尿路上皮癌の初期発生における遺伝子異常や細胞異型の形成の分子機構を解析しする。さらに分子病理学的機構や遺伝子異常を元に、尿路上皮癌の初期病変の病理組織学的診断基準を定義し、臨床病理学的特徴を明らかにする。

 
201
Projects
USD 107.8 M
Aggregated funding amount
USD 714 K
Average funding amount
Project list item
Roles of epigenetic regulators in bladder cancer progression

University of California - Cancer Research Coordinating Committee to Zhu Wang

USD 74,960
2020 - 2020
Project list item
Analysis of the antineoplastic action of Class I HDAC inhibitors to define new combination therapies for urothelial carcinoma

German Research Foundation to Günter Niegisch, Michèle Janine Hoffmann

 
2020 -
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Engineering Smart Solutions for Disorders of the Bladder Urothelium

Engineering and Physical Sciences Research Council

 
2019 - 2023
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Transdifferentiation of fibroblasts to urothelial progenitors for definitive urothelial replacement therapy in non-muscle invasive bladder cancer

Bladder Cancer Advocacy Network to Philip A Beachy, Kris Butalid Prado

USD 300,000
2019 - 2021
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Role of Fgfr2 signaling in bladder injury and regeneration

National Institute of Diabetes and Digestive and Kidney Diseases to CARLTON MATTHEW BATES

USD 234,750
2019 - 2022
Project list item
[Exploration of novel therapeutic molecules for urothelial cancer based on the molecular subtypes and metabolomics] - Original in Japanese

Japan Society for the Promotion of Science to Norihiko TSUCHIYA, Toshihiko Sakurai, Sei Naito

USD 39,492
2019 - 2022
Project list item
[Biomarker screening of urothelial carcinoma using liquid biopsy] - Original in Japanese

Japan Society for the Promotion of Science to Yuichiro Suzuki

USD 38,300
2019 - 2022
Project list item
[Elucidating anticancer drug resistance in urothelial carcinoma by multi-faceted approach] - Original in Japanese

Japan Society for the Promotion of Science to Masayuki NAKAGAWA, Hirofumi YOSHINO, Hideki ENOKIDA, 洋一 大迫

USD 40,693
2019 - 2022
Project list item
Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 372,404
2019 - 2021
Project list item
Defining the impact of intra-tumoral morphologic, immune and mutational heterogeneity in urothelial carcinoma

National Cancer Institute to HIKMAT AL-AHMADIE

USD 821,670
2019 - 2024
Project list item
Cell-biological mechanisms of the urinary bladder multifocal tumor formation (postdoctoral research project)

Slovenian Research Agency to Jerman Urška Dragin

 
2019 - 2021
Project list item
Clonal evolution and molecular stratification of urothelial carcinoma in situ of the urinary bladder

German Research Foundation to Stefan Garczyk, Nadine Gaisa

 
2019 -
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The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 90,032
2018 - 2021
Project list item
Modeling bladder cancer pathogenesis and tumor evolution

National Cancer Institute to CORY ABATE-SHEN, MICHAEL M. SHEN, DAVID B SOLIT, HIKMAT AL-AHMADIE

USD 3,432,927
2018 - 2023
Project list item
SPORE in Bladder Cancer

National Cancer Institute to DEAN F. BAJORIN, TIMOTHY AN-THY CHAN, MICHAEL STEPHEN GLICKMAN, IRINA OSTROVNAYA, HIKMAT AL-AHMADIE, DAVID B SOLIT

USD 4,438,686
2018 - 2023
Project list item
Upper tract urothelial carcinoma is non-basal and T-cell depleted

Bladder Cancer Advocacy Network to Panagiotis Vlachostergios

USD 1,700
2018 - 2018
Project list item
Next generation sequencing to enhance initial staging and dynamically monitor disease response in upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Philip Hilmi Abbosh, Wafik El-Deiry, Elizabeth Plimack

USD 50,000
2018 - 2020
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