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Similar Projects for

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[Elucidation of bladder cancer recurrence and progression mechanism focusing on lysophospholipid and establishment of new treatment]

Original in Japanese: Elucidation of bladder cancer recurrence and progression mechanism focusing on lysophospholipid and establishment of new treatment

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.9 M
USD 36 K
Funding amount
Abstract
[Urothelial cancer frequently occurs temporally and spatially, and high recurrence rate and progress rate are important problems. In recent years, research on physiologically active substances involved in cell movement and migration has been drawing attention. Attention has been focused on the effects of lysophosphatidic acid (LPA), a lysophospholipid, which is a constituent of the cell membrane lipid bilayer, on cell proliferation / migration, cancer invasion, and angiogenesis. It is currently attracting attention as a biomarker for various diseases. We have been studying the role of LPA receptor 1 (LPA1) in bladder cancer. In this study, we aim to develop new therapeutic agents by evolving in vitro research results into in vivo research, elucidating recurrence and invasion mechanism of urothelial cancer.]
Original in Japanese
尿路上皮癌は時間的、空間的に多発し、高い再発率、進展率が重大な問題である。近年、細胞の運動、遊走に関与する生理活性物質の研究が注目されている。細胞膜脂質二重層の構成物質であるリゾリン脂質の一つリゾフォスファチジン酸(LPA)の細胞増殖・遊走、がん浸潤、血管新生などへの作用が注目されている。様々な疾患のバイオマーカーとして注目されているところである。私たちはこれまでに、膀胱癌におけるLPA受容体1(LPA1)の役割に注目し研究を行ってきた。今回の研究ではこれまでのin vitroでの研究成果をin vivoでの研究に発展させ、尿路上皮癌の再発、浸潤メカニズムを解明し、新規治療薬の開発を目指す。

 
195
Projects
USD 123.3 M
Aggregated funding amount
USD 833 K
Average funding amount
Project list item
Defining NRF2 induced tumor invasion in bladder cancer

Bladder Cancer Advocacy Network to Yuki Kita, William Youngkwan Kim, Bernard Weissman

USD 50,000
2020 - 2021
Project list item
Roles of epigenetic regulators in bladder cancer progression

University of California - Cancer Research Coordinating Committee to Zhu Wang

USD 74,960
2020 - 2020
Project list item
Engineering Smart Solutions for Disorders of the Bladder Urothelium

Engineering and Physical Sciences Research Council

 
2019 - 2023
Project list item
Transdifferentiation of fibroblasts to urothelial progenitors for definitive urothelial replacement therapy in non-muscle invasive bladder cancer

Bladder Cancer Advocacy Network to Philip A Beachy, Kris Butalid Prado

USD 300,000
2019 - 2021
Project list item
Role of Fgfr2 signaling in bladder injury and regeneration

National Institute of Diabetes and Digestive and Kidney Diseases to CARLTON MATTHEW BATES

USD 234,750
2019 - 2022
Project list item
[Efficacy and toxicity of bladder instillation of anti-tumor peptide for inhibition of bladder tumor in mice] - Original in Japanese

Japan Society for the Promotion of Science to Toru SHIMAZUI, Kazuhiro YOSHIKAWA, Takahiro Kojima, Hiroyuki NISHIYAMA

USD 39,492
2019 - 2022
Project list item
[Exploration of novel therapeutic molecules for urothelial cancer based on the molecular subtypes and metabolomics] - Original in Japanese

Japan Society for the Promotion of Science to Norihiko TSUCHIYA, Toshihiko Sakurai, Sei Naito

USD 39,492
2019 - 2022
Project list item
[Biomarker screening of urothelial carcinoma using liquid biopsy] - Original in Japanese

Japan Society for the Promotion of Science to Yuichiro Suzuki

USD 38,300
2019 - 2022
Project list item
[Development of cancer immunotherapy for urothelial carcinoma targeting tissue infiltrating regulatory T cells] - Original in Japanese

Japan Society for the Promotion of Science to Atsunari Kawashima, 尚 和田, Norio NONOMURA

USD 39,492
2019 - 2022
Project list item
Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 372,404
2019 - 2021
Project list item
Defining the impact of intra-tumoral morphologic, immune and mutational heterogeneity in urothelial carcinoma

National Cancer Institute to HIKMAT AL-AHMADIE

USD 821,670
2019 - 2024
Project list item
Cell-biological mechanisms of the urinary bladder multifocal tumor formation (postdoctoral research project)

Slovenian Research Agency to Jerman Urška Dragin

 
2019 - 2021
Project list item
The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 90,032
2018 - 2021
Project list item
Urinary microbiota characterization of superficial bladder Cancer patients undergoing BCG immunotherapy

São Paulo Research Foundation to Anamaria Aranha Camargo

 
2018 - 2022
Project list item
Elucidating immunotherapy resistance mechanisms in non-T cell-inflamed bladder cancer

National Cancer Institute to RANDY F. SWEIS

USD 425,338
2018 - 2022
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
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