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Similar Projects for

Project

Modeling bladder cancer metastasis using human patient-derived tumor organoids

Funder: Bladder Cancer Advocacy Network

Funding period
USD 300 K
Funding amount
Abstract
The molecular mechanisms that regulate progression of bladder cancer to invasion and metastasis are poorly understood, in part due to the lack of suitable model systems that reflect the biology of the human disease. In recent work, we have used three-dimensional culture approaches to establish a novel biobank of human patient-derived organoids from primary bladder tumors. These organoid lines recapitulate the histopathological and molecular diversity of non-muscle invasive bladder cancer as well as muscle invasive bladder cancer, and can be readily converted into xenografts by orthotopic transplantation. We hypothesize that these patient-derived organoid lines represent a suitable model for functional analyses of bladder cancer metastasis, and will therefore pursue three specific aims: 1) Investigation of tumor invasiveness in organoid culture to examine the roles of extracellular matrix and tumor-specific mutations in conferring invasive properties to bladder tumor cells; 2) Molecular analysis of metastasis by orthotopic transplantation of organoids to analyze the metastatic ability of organoid-derived xenografts in vivo; and 3) Investigation of collective invasion and dissemination using multi-color organoids to determine whether metastasis is mediated by single cells or multicellular (collective) clusters. Overall, this proposal represents a highly innovative project that uses human patient-derived tumor organoids to identify tumor cell autonomous and microenvironmental factors that regulate progression to metastatic bladder cancer.

 
452
Projects
USD 226.5 M
Aggregated funding amount
USD 550 K
Average funding amount
Project list item
Chromatin Modifier Gene Mutation and Enhancer Dysfunction in Bladder Cancer

National Cancer Institute to BYRON H LEE

USD 243,205
2019 - 2024
Project list item
Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 203,510
2019 - 2021
Project list item
Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder - (ADAPT-BLADDER)

National Cancer Institute to NOAH M HAHN

USD 656,816
2019 - 2024
Project list item
Defining the impact of intra-tumoral morphologic, immune and mutational heterogeneity in urothelial carcinoma

National Cancer Institute to HIKMAT AL-AHMADIE

USD 410,835
2019 - 2024
Project list item
The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 45,016
2018 - 2021
Project list item
Modeling bladder cancer pathogenesis and tumor evolution

National Cancer Institute to CORY ABATE-SHEN, MICHAEL M. SHEN, DAVID B SOLIT, HIKMAT AL-AHMADIE

USD 1,765,498
2018 - 2023
Project list item
Elucidating immunotherapy resistance mechanisms in non-T cell-inflamed bladder cancer

National Cancer Institute to RANDY F. SWEIS

USD 212,669
2018 - 2022
Project list item
Novel recombinant BCG for immunotherapy of bladder cancer

National Cancer Institute to BORIS SHOR

USD 290,014
2018 - 2019
Project list item
Elucidating Mechanisms of Bladder Cancer Metastasis

European Commission to Prasanna IYENGAR

USD 204,256
2018 - 2020
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
Project list item
Unraveling disparate roles of Notch-1 and Notch-2 signaling in bladder cancer.

Michael Smith Foundation for Health Research to Peter C Black

USD 338,302
2018 - 2023
Project list item
Role of B-arrestins in bladder cancer progression and response to chemotherapy

United States Department of Veterans Affairs to BAL L LOKESHWAR

 
2018 - 2022
Project list item
Intra-operative MRI-guided Robotic System for Photothermal Therapy of Bladder Cancer

University Grants Committee to Kwok Ka Wai, TEOH Yuen Chun Jeremy, Vardhanabhuti Varut Vince, Wong Kenneth Kin Yip

USD 80,682
2018 - 2021
Project list item
Transurethral En Bloc Versus Standard Resection of Bladder Tumour: A Multi-centre Randomised Controlled Trial (EB-StaR study).

University Grants Committee to TEOH Yuen Chun Jeremy

USD 75,274
2018 - 2020
Project list item
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer

United States Department of Veterans Affairs to CHONG-XIAN PAN

 
2018 - 2022
Project list item
[Molecular mechanism of bladder cancer invasion and metastasis focusing on invadopodia, exosome, and hyaluronidase] - Original in Japanese

Japan Society for the Promotion of Science to 範子 得居

USD 38,160
2018 - 2021
Project list item
Deciphering the neoantigen landscape in bladder cancer patients

Swiss National Science Foundation to Laurent Derré

USD 639,521
2018 - 2022
Project list item
Ty21a immunotherapy of non-muscle-invasive bladder cancer

Swiss National Science Foundation to Denise Nardelli Haefliger

USD 436,670
2018 - 2021
Project list item
CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

Patient-Centered Outcomes Research Institute to John Gore

USD 8,500,000
2018 - 2022
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