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Modeling bladder cancer metastasis using human patient-derived tumor organoids

Funder: Bladder Cancer Advocacy Network

Funding period
USD 300 K
Funding amount
The molecular mechanisms that regulate progression of bladder cancer to invasion and metastasis are poorly understood, in part due to the lack of suitable model systems that reflect the biology of the human disease. In recent work, we have used three-dimensional culture approaches to establish a novel biobank of human patient-derived organoids from primary bladder tumors. These organoid lines recapitulate the histopathological and molecular diversity of non-muscle invasive bladder cancer as well as muscle invasive bladder cancer, and can be readily converted into xenografts by orthotopic transplantation. We hypothesize that these patient-derived organoid lines represent a suitable model for functional analyses of bladder cancer metastasis, and will therefore pursue three specific aims: 1) Investigation of tumor invasiveness in organoid culture to examine the roles of extracellular matrix and tumor-specific mutations in conferring invasive properties to bladder tumor cells; 2) Molecular analysis of metastasis by orthotopic transplantation of organoids to analyze the metastatic ability of organoid-derived xenografts in vivo; and 3) Investigation of collective invasion and dissemination using multi-color organoids to determine whether metastasis is mediated by single cells or multicellular (collective) clusters. Overall, this proposal represents a highly innovative project that uses human patient-derived tumor organoids to identify tumor cell autonomous and microenvironmental factors that regulate progression to metastatic bladder cancer.

USD 303.4 M
Aggregated funding amount
USD 584 K
Average funding amount
Project list item
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer


USD 703,400
2020 - 2025
Project list item
Chimeric RNAs and their implication in lymphatic metastasis of bladder cancer

National Cancer Institute to HUI LI

USD 205,913
2020 - 2025
Project list item
CD40 agonism for the treatment of bladder cancer

National Cancer Institute to CHRISTOPHER STUART GARRIS

USD 64,554
2020 - 2023
Project list item
A new bladder cancer model based on tissue reprogramming and gene targeting

National Cancer Institute to FLAMINIA TALOS, DAIFENG WANG

USD 203,843
2020 - 2021
Project list item
Roles of epigenetic regulators in bladder cancer progression

University of California - Cancer Research Coordinating Committee to Zhu Wang

USD 74,960
2020 - 2020
Project list item
Engineering Smart Solutions for Disorders of the Bladder Urothelium

Engineering and Physical Sciences Research Council

2019 - 2023
Project list item
Bladder cancer chemotherapy potentiation with a multiprong arachidonic acid pathway modulator

National Cancer Institute to PAUL THOMAS HENDERSON

USD 300,000
2019 - 2020
Project list item
Implementing Risk-aligned Bladder Cancer Surveillance

United States Department of Veterans Affairs to FLORIAN R SCHROECK

2019 - 2023
Project list item
[The association between SORL1 and advanced bladder cancer] - Original in Japanese

Japan Society for the Promotion of Science to Takanobu UTSUMI

USD 26,335
2019 - 2021
Project list item
Developing a SMART scaffold for bladder augmentation

National Institute of Biomedical Imaging and Bioengineering to GUILLERMO ANTONIO AMEER, ARUN SHARMA, JOHN ROGERS

USD 709,004
2019 - 2023
Project list item
Investigating underlying molecular mechanisms of epigenetic therapies in muscle-invasive bladder cancer

Bladder Cancer Advocacy Network to Swathi Ramakrishnan

USD 1,700
2019 - 2019
Project list item
Transdifferentiation of fibroblasts to urothelial progenitors for definitive urothelial replacement therapy in non-muscle invasive bladder cancer

Bladder Cancer Advocacy Network to Philip A Beachy, Kris Butalid Prado

USD 300,000
2019 - 2021
Project list item
Understanding the Burden and Impact of Financial Toxicity in Bladder Cancer: A Mixed Methods Study of 2 Diverse Patient Populations

Bladder Cancer Advocacy Network to Sumeet Kaur Bhanvadia, Siamak Daneshmand, Reginald Tucker-Seeley

USD 50,000
2019 - 2020
Project list item
Recombinant CCL2 as a novel treatment strategy for bladder cancer

Bladder Cancer Advocacy Network to Neelam Mukherjee, Robert Scott Svatek

USD 50,000
2019 - 2020
Project list item
Refined phenotyping and personalized targeting of muscle-invasive bladder cancer

Swiss National Science Foundation to Roland Seiler, Eugenio Zoni, Vera Genitsch, Martina Minoli, Marianna Kruithof-de Julio, Franziska Singer, Federico La Manna, Kiu Yan Charlotte Ng

USD 709,398
2019 - 2023
Project list item
Identifying Immunological Basis for Bladder Cancer Sex Bias

Canadian Institutes of Health Research to Hyunwoo Kwon, Zihai Li

USD 26,376
2019 - 2022
Project list item
[Efficacy and toxicity of bladder instillation of anti-tumor peptide for inhibition of bladder tumor in mice] - Original in Japanese

Japan Society for the Promotion of Science to Toru SHIMAZUI, Takahiro KOJIMA, Hiroyuki NISHIYAMA, Kazuhiro YOSHIKAWA

USD 39,492
2019 - 2022
Project list item
DNA adductome of human bladder from the tobacco exposome

National Institute of Environmental Health Sciences to ROBERT J. TURESKY

USD 922,448
2019 - 2023
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