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Project

Novel 3D personalized bladder cancer model on demand: A new era for personalized medicine.

Funder: Canadian Institutes of Health Research

Funding period
CAD 62 K
USD 48 K
Funding amount
Abstract
Bladder cancer (BC) is the 5th most commonly diagnosed cancer in Canada. It is usually manifested as 'superficial' BC. However, 25% of patients progress to a more aggressive and potentially lethal state. Recent studies of BC have revealed several distinct subtypes emphasising the need for an individualized approach. Our group has successfully established a bladder cell removal (decellularization) protocol. These acellular bladders have been seeded with normal bladder cells and grown for up to 1 month showing adequate cell survival. These preliminary results proved to us the feasibility and great potential of engineering bladder tissues. Here we propose to develop a 3D BC model, on demand, using acellular bladder scaffolds as a platform, which will enable us to recreate a BC of a specific patient to test and/or develop drugs. The development of this model will potentially make a step forward on how we currently test anti-cancer drugs. Each 3D BC tissue constructed, will be identical to a specific patient undergoing bladder cancer. This approach will have the potential to simultaneously test multiple anti-cancer drugs before giving the appropriate one to the patient, avoiding sequential unnecessary treatments and reducing side effects which will ultimately improve patient's quality of life. Our model system is a novel approach that will aid in: the mechanistic studies of cell-cell interaction; provide a platform to test and develop new drugs; reduce the number of animals used for experimentation; and, provide a model for preclinical treatment evaluation before deciding on a personalized therapy. At the conclusion of this project we hope to have developed a new tool that will significantly impact the way we currently treat bladder cancer patients.

 
622
Projects
USD 329.6 M
Aggregated funding amount
USD 579 K
Average funding amount
Project list item
Chromatin Modifier Gene Mutation and Enhancer Dysfunction in Bladder Cancer

National Cancer Institute to BYRON H LEE

USD 243,205
2019 - 2024
Project list item
Raman Endoscopic Proteo-lipidomics of Bladder Cancer

European Research Council to Mads SYLVEST BERGHOLT

USD 1,705,861
2019 - 2024
Project list item
Combatting Bladder Cancer by Inducing Epithelial Turnover

National Cancer Institute to SOMAN N ABRAHAM

USD 203,510
2019 - 2021
Project list item
Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder - (ADAPT-BLADDER)

National Cancer Institute to NOAH M HAHN

USD 656,816
2019 - 2024
Project list item
Defining the impact of intra-tumoral morphologic, immune and mutational heterogeneity in urothelial carcinoma

National Cancer Institute to HIKMAT AL-AHMADIE

USD 410,835
2019 - 2024
Project list item
The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 45,016
2018 - 2021
Project list item
Modeling bladder cancer pathogenesis and tumor evolution

National Cancer Institute to CORY ABATE-SHEN, MICHAEL M. SHEN, DAVID B SOLIT, HIKMAT AL-AHMADIE

USD 1,765,498
2018 - 2023
Project list item
Elucidating immunotherapy resistance mechanisms in non-T cell-inflamed bladder cancer

National Cancer Institute to RANDY F. SWEIS

USD 212,669
2018 - 2022
Project list item
Ultrasound-based diagnostic and monitoring of bladder cancer treatment with drug released from nanoparticles

National Cancer Institute to JOE ASSOULINE, YI LUO

USD 350,240
2018 - 2020
Project list item
Novel recombinant BCG for immunotherapy of bladder cancer

National Cancer Institute to BORIS SHOR

USD 290,014
2018 - 2019
Project list item
Elucidating Mechanisms of Bladder Cancer Metastasis

European Commission to Prasanna IYENGAR

USD 204,256
2018 - 2020
Project list item
DT-EGF Toxic Fusion Protein for the Treatment of Bladder Cancer

National Cancer Institute to MIKE GLODE, SHAWN PATRICK ZINNEN

USD 299,937
2018 - 2019
Project list item
SPORE in Bladder Cancer

National Cancer Institute to DEAN F. BAJORIN, DAVID B SOLIT, MICHAEL STEPHEN GLICKMAN, TIMOTHY AN-THY CHAN, HIKMAT AL-AHMADIE, IRINA OSTROVNAYA

USD 2,299,837
2018 - 2023
Project list item
Modeling bladder cancer metastasis using human patient-derived tumor organoids

Bladder Cancer Advocacy Network to Michael M Shen

USD 300,000
2018 - 2020
Project list item
Novel Biomarkers for the Clinical Management of Bladder Cancer

National Cancer Institute to VINATA B LOKESHWAR

USD 466,211
2018 - 2023
Project list item
Unraveling disparate roles of Notch-1 and Notch-2 signaling in bladder cancer.

Michael Smith Foundation for Health Research to Peter C Black

USD 338,302
2018 - 2023
Project list item
Regulation of Bladder Umbrella Cell Paracellular Permeability by Stretch

National Institute of Diabetes and Digestive and Kidney Diseases to AMITY FENN EATON

USD 44,524
2018 - 2021
Project list item
Hsp90B in Bladder Cancer

National Cancer Institute to BRIAN S J BLAGG

USD 365,328
2018 - 2022
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