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Project

Novel 3D personalized bladder cancer model on demand: A new era for personalized medicine.

Funder: Canadian Institutes of Health Research

Funding period
CAD 186 K
USD 142 K
Funding amount
Abstract
Bladder cancer (BC) is the 5th most commonly diagnosed cancer in Canada. It is usually manifested as 'superficial' BC. However, 25% of patients progress to a more aggressive and potentially lethal state. Recent studies of BC have revealed several distinct subtypes emphasising the need for an individualized approach. Our group has successfully established a bladder cell removal (decellularization) protocol. These acellular bladders have been seeded with normal bladder cells and grown for up to 1 month showing adequate cell survival. These preliminary results proved to us the feasibility and great potential of engineering bladder tissues. Here we propose to develop a 3D BC model, on demand, using acellular bladder scaffolds as a platform, which will enable us to recreate a BC of a specific patient to test and/or develop drugs. The development of this model will potentially make a step forward on how we currently test anti-cancer drugs. Each 3D BC tissue constructed, will be identical to a specific patient undergoing bladder cancer. This approach will have the potential to simultaneously test multiple anti-cancer drugs before giving the appropriate one to the patient, avoiding sequential unnecessary treatments and reducing side effects which will ultimately improve patient's quality of life. Our model system is a novel approach that will aid in: the mechanistic studies of cell-cell interaction; provide a platform to test and develop new drugs; reduce the number of animals used for experimentation; and, provide a model for preclinical treatment evaluation before deciding on a personalized therapy. At the conclusion of this project we hope to have developed a new tool that will significantly impact the way we currently treat bladder cancer patients.

 
978
Projects
USD 473.0 M
Aggregated funding amount
USD 621 K
Average funding amount
Project list item
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer

National Cancer Institute to NINA BHARDWAJ, MATTHEW GALSKY, JUN ZHU

USD 703,400
2020 - 2025
Project list item
Chimeric RNAs and their implication in lymphatic metastasis of bladder cancer

National Cancer Institute to HUI LI

USD 205,913
2020 - 2025
Project list item
CD40 agonism for the treatment of bladder cancer

National Cancer Institute to CHRISTOPHER STUART GARRIS

USD 64,554
2020 - 2023
Project list item
Effect of APOBEC3 on Bladder Cancer Biology and Response to Immunotherapy

National Cancer Institute to ANDREW TRUONG

USD 45,016
2020 - 2023
Project list item
A new bladder cancer model based on tissue reprogramming and gene targeting

National Cancer Institute to FLAMINIA TALOS, DAIFENG WANG

USD 203,843
2020 - 2021
Project list item
Roles of epigenetic regulators in bladder cancer progression

University of California - Cancer Research Coordinating Committee to Zhu Wang

USD 74,960
2020 - 2020
Project list item
Quantifying Risk and Resilience (R2) among Patients with Bladder Cancer: A Novel Personalized, Comprehensive Risk Stratification Program

Bladder Cancer Advocacy Network to Sarah Psutka, Jonathan Wright, Daniel Lin, John Gore, Ryan O'Malley, Anne Browning, Florian Fintelmann

USD 50,000
2020 - 2021
Project list item
Engineering Smart Solutions for Disorders of the Bladder Urothelium

Engineering and Physical Sciences Research Council

 
2019 - 2023
Project list item
Bladder cancer chemotherapy potentiation with a multiprong arachidonic acid pathway modulator

National Cancer Institute to PAUL THOMAS HENDERSON

USD 300,000
2019 - 2020
Project list item
Implementing Risk-aligned Bladder Cancer Surveillance

United States Department of Veterans Affairs to FLORIAN R SCHROECK

 
2019 - 2023
Project list item
[The association between SORL1 and advanced bladder cancer] - Original in Japanese

Japan Society for the Promotion of Science to Takanobu UTSUMI

USD 26,335
2019 - 2021
Project list item
Geriatric Conditions and Treatment Burden in Older Adults with Non-Muscle-Invasive Bladder Cancer and Their Caregivers

National Institute on Aging to TULLIKA GARG

USD 135,849
2019 - 2021
Project list item
Developing a SMART scaffold for bladder augmentation

National Institute of Biomedical Imaging and Bioengineering to GUILLERMO ANTONIO AMEER, ARUN SHARMA, JOHN ROGERS

USD 709,004
2019 - 2023
Project list item
Investigating underlying molecular mechanisms of epigenetic therapies in muscle-invasive bladder cancer

Bladder Cancer Advocacy Network to Swathi Ramakrishnan

USD 1,700
2019 - 2019
Project list item
Transdifferentiation of fibroblasts to urothelial progenitors for definitive urothelial replacement therapy in non-muscle invasive bladder cancer

Bladder Cancer Advocacy Network to Philip A Beachy, Kris Butalid Prado

USD 300,000
2019 - 2021
Project list item
PFI-TT: The Development of Flow-Through Sensors for the Detection of Bladder Cancer in Urine Samples

Directorate for Engineering to James McGrath, James Roussie

USD 249,435
2019 - 2021
Project list item
Role of Fgfr2 signaling in bladder injury and regeneration

National Institute of Diabetes and Digestive and Kidney Diseases to CARLTON MATTHEW BATES

USD 234,750
2019 - 2022
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