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Similar Projects for

Project

Recovery Support for Bladder CA Patients and Caregivers: A Multimodal Approach

Funder: National Cancer Institute

Funding period
USD 1.4 M
Funding amount
Abstract
ABSTRACT Treatment for muscle invasive bladder cancer (MIBC) involves the removal of the bladder and construction of a new voiding system and is physically and psychologically profoundly challenging for patients and caregivers. Based on our published literature and extensive pilot data, patients and caregivers have extensive unmet informational, social, psychological, instrumental, and medical needs from the time of diagnosis, through treatment and recovery which are not adequately addressed by health care professionals. We propose to address these unmet needs through the refinement and evaluation of a comprehensive, 2-part (in-person and web-based) intervention, geared towards the patient and caregiver. Specifically, during Aim 1, the formative phase, we propose to further refine our newly developed intervention components with the help of an established patient/caregiver advisory board. The intervention, Recovery Support for Bladder Cancer (RSBC), consists of a pre-treatment, in-person preparatory instructional session with a trained health care professional (Module 1) to equip patients and caregivers with the skills to adjust to the upcoming treatment and recovery period. This is followed by a post-treatment, interactive web-based program (Module 2) to provide further support for both patients and caregivers to enhance quality of life (QOL) and reduce infections and nurse/ER visits. The RSBC intervention will be evaluated in a 12-month randomized controlled trial (Aim 2) among patients and caregiver dyads (N=330 initial; 230 final sample) against a time and attention comparison condition that incorporates standard of care discharge instructions and modules focusing on wellness. Primary outcomes for both patients and caregivers will be improved QOL, which is hypothesized to be significantly higher among participants randomized into RSBC. Secondary outcomes will be fewer infections and nurse- ER visits for patients randomized into RSBC. Aim 3 proposes moderator (i.e., age, gender, surgical diversion type) and mediator (i.e., patient activation, distress) analyses of intervention efficacy. We hypothesize that RSBC will be significantly more successful among (a) older, (b) female participants, and (c) patients with a conduit diversion type. Elevated levels of patient activation (i.e., higher self-care knowledge, self-efficacy, lower distress) will mediate the intervention effects. Exploratory Aim 4 will examine the costs and potential savings associated with developing and implementing the RSBC intervention. We hypothesize that initial development and implementation costs of RSBC will be offset by reduced nurse/ER visits. The scientific premise is strong and supported by an established theoretical framework, extensive pilot data and a rigorous application of clinical research methods. The proposed study is highly innovative, as it comprehensively addresses unmet needs of both patients and caregivers from pre- and (immediate) post-treatment to recovery. This is achieved through an innovative combination of in-person preparation and skill-building and web-based technology. If successful, RSBC has the potential to significantly change clinical care for patients and caregivers with MIBC.

 
14
Projects
USD 17.7 M
Aggregated funding amount
USD 1.5 M
Average funding amount
Project list item
Implication of neutrophil extracellular traps in the efficacy of bladder-sparing therapy in muscle invasive bladder cancer

Canadian Institutes of Health Research to Wassim Kassouf, Jonathan David Spicer, Ciriaco A. Piccirillo

USD 138,878
2020 - 2025
Project list item
Geriatric Conditions and Treatment Burden in Older Adults with Non-Muscle-Invasive Bladder Cancer and Their Caregivers

National Institute on Aging to TULLIKA GARG

USD 271,698
2019 - 2021
Project list item
Comparing Two Treatment Options for Recurrent Bladder Cancer

Patient-Centered Outcomes Research Institute

USD 8,541,087
2018 - 2025
Project list item
Novel Approach to Enhance Ostomy Care in Patients with Bladder and Colorectal Cancer

National Institute of Nursing Research to NIHAL MOHAMED

USD 475,146
2017 - 2020
Project list item
Identifying Genomic Determinants of Chemoradiotherapy Response in Muscle-Invasive Bladder Cancer

Bladder Cancer Advocacy Network to Kent William Mouw, Alan D'Andrea, Jason Efstathiou, Anthony John Iafrate

USD 50,000
2016 - 2018
Project list item
Bladder Fiducial Markers and Diffusion-MRI to Optimize Bladder Chemo-Radiotherapy

National Cancer Institute to MAURICE MARCEL GARCIA

USD 1,574,130
2016 - 2023
Project list item
BladderPath: Image Directed Redesign of Bladder Cancer Treatment Pathways

NIHR Evaluation Trials and Studies Coordinating Centre to Nicholas James

USD 1,974,056
2016 - 2021
Project list item
Epigenetic regulation of bladder cancer progression

Bladder Cancer Advocacy Network to Cory Abate-Shen, Michael M Shen, David Brian Solit, Cathy Mendelsohn, Hikmat Al-Ahmadie, James M. McKiernan

USD 300,000
2015 - 2017
Project list item
Novel Approach to Facilitate Decisions in Patients w/ Muscle Invasive Bladder CA

National Cancer Institute to MICHAEL A DIEFENBACH, MATTHEW GALSKY

USD 449,777
2015 - 2018
Project list item
Urinary Diversion Among Bladder Cancer Survivors: Cost, Complications, and QOL

National Cancer Institute to CARMIT KURN MCMULLEN

USD 3,080,828
2012 - 2018
Project list item
From Diagnosis to Survivorship: Bladder Cancer Survivors Unmet Needs

National Cancer Institute to NIHAL MOHAMED

USD 163,785
2012 - 2014