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Similar Projects for

Project

Hsp90B in Bladder Cancer

Funder: National Cancer Institute

Funding period
USD 1.1 M
Funding amount
Abstract
The development of new methods to treat cancer is greatly needed. The Hsp90 protein folding machinery has been the target of significant interest for the development of anti-cancer agents. However, Hsp90 is responsible for the folding of ~300 protein folding substrates, which may lead to undesired on-target toxicity and may be responsible for many of the Hsp90-targeted drugs that have failed in clinical trials. Through a structure-based approach, an isoform-selective inhibitor of Hsp90 has been identified and shown to exhibit good selectivity and affinity against particular cancers. Consequently, the goal of this application is to optimize this new inhibitory scaffold for great affinity/efficacy, to evaluate the role of a specific Hsp90 isoform in cancer, and to validate this isoform as a target for the treatment of bladder cancer.

 
99
Projects
USD 49.0 M
Aggregated funding amount
USD 557 K
Average funding amount
Project list item
[The association between SORL1 and advanced bladder cancer] - Original in Japanese

Japan Society for the Promotion of Science to Takanobu UTSUMI

USD 26,335
2019 - 2021
Project list item
Developing a SMART scaffold for bladder augmentation

National Institute of Biomedical Imaging and Bioengineering to GUILLERMO ANTONIO AMEER, ARUN SHARMA, JOHN ROGERS

USD 1,399,891
2019 - 2023
Project list item
The role of a new molecular driver in bladder cancer

National Cancer Institute to DALEY MORERA

USD 90,032
2018 - 2021
Project list item
Novel 3D personalized bladder cancer model on demand: A new era for personalized medicine.

Canadian Institutes of Health Research to Alan I So, Claudia Itze Chavez-munoz

USD 188,495
2018 - 2020
Project list item
Further Development of Multi-Antigen Vaccines for Primary and Secondary Prevention of Bladder Cancer

National Cancer Institute to CLINTON GRUBBS

USD 231,523
2018 - 2020
Project list item
Novel recombinant BCG for immunotherapy of bladder cancer

National Cancer Institute to BORIS SHOR

USD 290,014
2018 - 2020
Project list item
DT-EGF Toxic Fusion Protein for the Treatment of Bladder Cancer

National Cancer Institute to MIKE GLODE, SHAWN PATRICK ZINNEN

USD 299,937
2018 - 2020
Project list item
Prevention of Urinary Bladder Cancer with Two Clinically-Ready Agents (Everolimus andNaproxen) When Administered in Combination

National Cancer Institute to CLINTON GRUBBS

USD 709,567
2018 - 2021
Project list item
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer

United States Department of Veterans Affairs to CHONG-XIAN PAN

 
2018 - 2022
Project list item
Investigation of the Tumor Microenvironment as a Protective Niche That Supports Treatment Resistance of Bladder Cancer

Congressionally Directed Medical Research Programs to Joshua J Meeks

USD 576,132
2017 - 2018
Project list item
Dissecting the Interface Between ARID1A and mRNA Translation in Bladder Cancer

Congressionally Directed Medical Research Programs to Sujata Jana

USD 264,000
2017 - 2018
Project list item
Targeting the Regulation and Actions of Telomerase Reverse Transcriptase (TERT) in Bladder Cancer

Congressionally Directed Medical Research Programs to Dan Theodorescu

USD 1,482,998
2017 - 2018
Project list item
INTRAVESICAL ONCOLYTIC THERAPY FOR BLADDER CANCER

National Cancer Institute to ROSA MARIA DIAZ, LUKKANA SUKSANPAISAN, BRADLEY C. LEIBOVICH

USD 1,990,950
2017 - 2020
Project list item
Multi-Antigen Vaccines for the Primary and Secondary Prevention of Bladder CancerTO POP: 9/15/2017 - 3/14/2019

National Cancer Institute to CLINTON GRUBBS

USD 636,313
2017 - 2019
Project list item
[Molecular mechanisms of androgen receptor signals in bladder cancer] - Original in Japanese

Japan Society for the Promotion of Science to Koji IZUMI, Hiroji UEMURA, Takashi Kawahara

USD 42,460
2017 - 2020
Project list item
Investigating the Role of the Tumor MicroEnvironment in Resistance of Urothelial Carcinoma of the Bladder to FGFR3 Inhibition

National Cancer Institute to CHERYL CLAUNCH-RABE

USD 198,600
2017 - 2021
Project list item
Defining the role of the androgen receptor low molecular weight isoforms in bladder cancer

United States Department of Veterans Affairs to MARIA MUDRYJ

 
2017 - 2020
Project list item
The Role of EZH2 in Non-Muscle Invasive Bladder Cancer

United States Department of Veterans Affairs to JOSHUA JAMES MEEKS

 
2016 - 2020
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