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Project

Ascertaining the role of mutations in COMPASS-like complex members in the development of upper tract urothelial carcinoma

Funder: Bladder Cancer Advocacy Network

Funding period
USD 50 K
Funding amount
Abstract
Upper tract urothelial carcinoma (UTUC) is a relatively rare malignancy and only accounts for 5-10% of all urothelial carcinomas. Nonetheless, management of high risk UTUC requiring radical nephrouretrectomy remains particularly challenging since only select patients have adequate renal function to tolerate cisplatin-based chemotherapy and few other proven therapeutic options exist. Cisplatin-ineligible patients with recurrent or metastatic disease who do not respond to immunotherapy have a dismal prognosis. Recent genomic studies have identified mutations in Complex of Proteins Associated with Set1(COMPASS)-like complex members in 66% of UTUC patients, but how these mutations drive UTUC carcinogenesis is virtually unknown. Our research is focused on how inactivating mutations in the COMPASS-like complex members, KMT2C, KMT2D, and KDM6A, lead to gene expression changes that support UTUC initiation and progression. In addition, we are exploring whether these mutations create a dependency on specific signaling pathways that can be exploited using novel therapies.

 
10
Projects
USD 829 K
Aggregated funding amount
USD 92 K
Average funding amount
Project list item
Upper tract urothelial carcinoma is non-basal and T-cell depleted

Bladder Cancer Advocacy Network to Panagiotis Vlachostergios

USD 1,700
2018 - 2018
Project list item
Next generation sequencing to enhance initial staging and dynamically monitor disease response in upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Philip Hilmi Abbosh, Wafik El-Deiry, Elizabeth Plimack

USD 50,000
2018 - 2020
Project list item
Development of novel diagnostic procedure for detection of upper urinary tract urothelial cancer

Japan Society for the Promotion of Science to Junichi Inokuchi, Masaharu MURATA, Yoshiki KATAYAMA, JEONG-HUN KANG, 圭二郎 清島, Arthur P. Grollman

USD 42,366
2016 - 2019
Project list item
The likelihood of underlying Lynch syndrome in upper tract urothelial carcinoma patients

Japan Society for the Promotion of Science to Masaya ITO

USD 21,145
2016 - 2018
Project list item
Investigation of anti-tumor effect of Axl kinase inhibitor in urothelial carcinoma.

Japan Society for the Promotion of Science to Seiya Hattori

USD 33,260
2014 - 2016
Project list item
Staging of upper tract urothelial cancer with optical coherence tomography

National Cancer Institute to ANDREW MARTIN ROLLINS, HUI ZHU

USD 548,995
2012 - 2015
Project list item
The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma

Japan Society for the Promotion of Science to Nobuyuki TANAKA

USD 45,791
2012 - 2014
Project list item
Risk group stratification to predict prognosis in Japanese patients with urothelial carcinoma

Japan Society for the Promotion of Science to Shigeru SAKANO

USD 52,673
2012 - 2015
Project list item
metastasized site-specific molecular targeted therapy utilizing redox signaling in urothelial carcinoma

Japan Society for the Promotion of Science to Takeshi SODA, Koji YOSHIMURA, Hiroyuki NISHIYAMA, Osamu OGAWA, Takeshi TAKAHASHI

USD 33,228
2006 - 2007