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Project

Investigation of anti-tumor effect of Axl kinase inhibitor in urothelial carcinoma.

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.8 M
USD 33 K
Funding amount
Abstract
We analyzed Axl-Gas6 signal cascade using both UMUC3 and HT1376 cell lines, which are commercially purchasable UC cell lines. We used Western blotting analysis and immune-staining analysis. HT1376 is weak Axl-staining cell line and UMUC3 is a weak Axl-staining cell line. Commercially purchasable Axl kinase inhibitor, R428, had no cytotoxic ability in itself, but it blocks invasive capacity store-dependently in UMUC3 cell line. The protein expression of Axl and Gas6 by immunohistochemistry and its correlation with clinicopathologic features were investigated in surgical specimens obtained from patients who had been surgically treated for UTUC. Axl protein expression and its ligand Gas6 protein expression associate with each other, and both of them highly associated with worse prognosis of UTUC patients treated by radical nephroureterectomy.

 
17
Projects
USD 5.1 M
Aggregated funding amount
USD 298 K
Average funding amount
Project list item
Characterization of Nectin-4 expression in molecular subtypes of urothelial cancer and mechanisms of resistance to enfortumab vedotin

Bladder Cancer Advocacy Network to Carissa Ellen Chu

USD 1,700
2020 - 2020
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
Project list item
Upper tract urothelial carcinoma is non-basal and T-cell depleted

Bladder Cancer Advocacy Network to Panagiotis Vlachostergios

USD 1,700
2018 - 2018
Project list item
Next generation sequencing to enhance initial staging and dynamically monitor disease response in upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Philip Hilmi Abbosh, Wafik El-Deiry, Elizabeth Plimack

USD 50,000
2018 - 2020
Project list item
Ascertaining the role of mutations in COMPASS-like complex members in the development of upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Byron H Lee, Nima Sharifi, Ming Hu, Daniel Kim

USD 50,000
2017 - 2018
Project list item
Development of novel diagnostic procedure for detection of upper urinary tract urothelial cancer

Japan Society for the Promotion of Science to Junichi Inokuchi, Masaharu MURATA, Yoshiki KATAYAMA, JEONG-HUN KANG, 圭二郎 清島, Arthur P. Grollman

USD 42,366
2016 - 2019
Project list item
The likelihood of underlying Lynch syndrome in upper tract urothelial carcinoma patients

Japan Society for the Promotion of Science to Masaya ITO

USD 21,145
2016 - 2018
Project list item
Epithelial to mesenchymal transition thorough GEP100-Arf6-AMAP1 pathway in urothelial cancer

Japan Society for the Promotion of Science to Tatsuaki Daimon

USD 34,348
2015 - 2017
Project list item
Antitumor effect by regulation of EZH2 on urothelial carcinoma

Japan Society for the Promotion of Science to NOZOMI HAYAKAWA, Eiji KIKUCHI, Akira MIYAJIMA, Mototsugu OYA

USD 35,497
2015 - 2017
Project list item
Characterization of Met signaling in urothelial carcinoma of the bladder

Bladder Cancer Advocacy Network to Young Hwan Lee

USD 1,500
2014 - 2014
Project list item
A treatment strategy targeting ERBB2 to overcome chemoradiation resistance in muscle-invasive bladder cancer

Japan Society for the Promotion of Science to Masaharu INOUE

USD 33,637
2014 - 2017
Project list item
Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer

Japan Society for the Promotion of Science to Eiji KIKUCHI, TAKEO KOSAKA, Akira MIYAJIMA

USD 45,237
2014 - 2017
Project list item
Targeting the MET Pathway in Urothelial Carcinoma

National Cancer Institute to ANDREA APOLO

USD 4,098,298
2014 - 2019
Project list item
Specific inhibition of Notch2 as a novel therapy for invasive bladder cancer

Canadian Institutes of Health Research to Tetsutaro Hayashi

USD 969
2013 - 2013
Project list item
Staging of upper tract urothelial cancer with optical coherence tomography

National Cancer Institute to ANDREW MARTIN ROLLINS, HUI ZHU

USD 548,995
2012 - 2015
Project list item
The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma

Japan Society for the Promotion of Science to Nobuyuki TANAKA

USD 45,791
2012 - 2014
Project list item
Novel pathological parameters in regional lymph nodes of urothelial carcinoma focused on "Seed and Soil" theory

Japan Society for the Promotion of Science to Takashige ABE

USD 48,220
2010 - 2011