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Staging of upper tract urothelial cancer with optical coherence tomography

Funder: National Cancer Institute

Funding period
USD 549 K
Funding amount
DESCRIPTION (provided by applicant): Diagnosis and treatment of upper-tract urothelial carcinomas (UTUC) remain very challenging for urologists. Standard management for many years has been radical nephroureterectomy (RNU). However, RNU is a significant over-treatment for low-risk tumors, which have low rate of progression. Endoscopic management of these low-risk cases bears obvious advantages over RNU, including lower co-morbidity and lower cost, and would be highly feasible if accurate diagnosis can be made. The success of endoscopic management relies on accurate identification of low-grade and low-stage tumors, but staging of UTUC is very difficult even through biopsy. Usually, adequate tissue specimens for pathohistological staging cannot be acquired because of the limited manipulation space in the ureter and renal pelvis and the potential risk of perforating thin ureteral wall if deep biopsyis attempted. Therefore, urologists typically make a diagnosis only based on the tumor grade, which is also inefficient because of the limitations of biopsy, and which, alone, is not sufficientto make certain treatment decisions. Therefore, if the stage of UTUC could be safely and reliably identified, urologists would have complete information for diagnosis, which could significantly improve endoscopic management of UTUC. We propose to stage UTUC through endoscopic optical coherence tomography (OCT). The feasibility of this in situ imaging approach is supported by the fact that OCT has already been shown to be able to stage bladder urothelial cancer, which is histologically similar to UTUC and uses the same staging system as UTUC. We have demonstrated that OCT can acquire high-quality images of the ureter through a probe ex vivo. In this project, we will implement OCT probes specifically for imaging of UTUC and test the safety and preliminary efficacy of staging of UTUC in a two-stage pilot study, including a training stage and a testing stage. Success of this project will result in: (a) an endoscopic OCT system designed and proven safe for UTUC imaging, (b) tested OCT image-based diagnostic criteria, and (c) a preliminary estimate of the accuracy of OCT staging of UTUC. This will justify and set the stage for larger scale clinical validation.

USD 6.9 M
Aggregated funding amount
USD 629 K
Average funding amount
Project list item
Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

European Commission

USD 5,009,004
2020 - 2023
Project list item
Upper tract urothelial carcinoma is non-basal and T-cell depleted

Bladder Cancer Advocacy Network to Panagiotis Vlachostergios

USD 1,700
2018 - 2018
Project list item
Next generation sequencing to enhance initial staging and dynamically monitor disease response in upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Philip Hilmi Abbosh, Wafik El-Deiry, Elizabeth Plimack

USD 50,000
2018 - 2020
Project list item
Ascertaining the role of mutations in COMPASS-like complex members in the development of upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Byron H Lee, Nima Sharifi, Ming Hu, Daniel Kim

USD 50,000
2017 - 2018
Project list item
Development of novel diagnostic procedure for detection of upper urinary tract urothelial cancer

Japan Society for the Promotion of Science to Junichi Inokuchi, Masaharu MURATA, Yoshiki KATAYAMA, JEONG-HUN KANG, 圭二郎 清島, Arthur P. Grollman

USD 42,366
2016 - 2019
Project list item
The likelihood of underlying Lynch syndrome in upper tract urothelial carcinoma patients

Japan Society for the Promotion of Science to Masaya ITO

USD 21,145
2016 - 2018
Project list item
Epithelial to mesenchymal transition thorough GEP100-Arf6-AMAP1 pathway in urothelial cancer

Japan Society for the Promotion of Science to Tatsuaki Daimon

USD 34,348
2015 - 2017
Project list item
Investigation of anti-tumor effect of Axl kinase inhibitor in urothelial carcinoma.

Japan Society for the Promotion of Science to Seiya Hattori

USD 33,260
2014 - 2016
Project list item
The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma

Japan Society for the Promotion of Science to Nobuyuki TANAKA

USD 45,791
2012 - 2014
Project list item
Risk group stratification to predict prognosis in Japanese patients with urothelial carcinoma

Japan Society for the Promotion of Science to Shigeru SAKANO

USD 52,673
2012 - 2015
Project list item
CRUK/11/027: POUT: Peri-Operative chemotherapy or sUrveillance in upper Tract urothelial cancer

Cancer Research UK to Emma Hall

2011 - 2020
Project list item
Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography

National Institute of Diabetes and Digestive and Kidney Diseases to YINGTIAN PAN

USD 1,574,825
2001 - 2010
Project list item
[Optische Kohärenztomographie (OCT) zur Diagnostik des Urothelkarzinoms in vivo] - Original in German

German Research Foundation to Frank König

2000 - 2003