Please enable JavaScript or talk to your local administrator to get JavaScript enabled.


Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy

Funder: European Commission

Funding period
EUR 4.5 M
USD 5.0 M
Funding amount
There is an absence of lasers with the necessary wavelengths and characteristics to access the possibilities for deeper high-resolution biological tissue imaging in the third bio-window between 1650 nm and 1870 nm. Motivated by recent breakthrough results in multi-photon imaging at twice the depths currently achievable, we will meet the urgent need for new sources to address the outstanding research questions in this spectral region. Results will guide and enable instrument development in this appealing and relatively unexplored biophotonics imaging wavelength range.

The AMPLITUDE consortium proposes a new concept of label-free, multi-modal microscopy and endoscopic imaging operating in this new wavelength region with multiple imaging and spectroscopic technologies, including NIR confocal reflectance microscopy, multi-photon microscopy and spontaneous Raman spectroscopy.

By progressing ultrafast fibre laser developments at 1700 nm, we will deliver new imaging capabilities in an appropriate form factor and at cost suitable for widespread adoption. This will be further enhanced by providing additional output at 850 nm using second harmonic generation from one integrated laser device.

This will enable a pioneering new compact and efficient multi-modal capability combining confocal and non-linear imaging techniques, overcoming performance limitations in medical and biological imaging applications, including improved pathohistological staging of tumours and in-vivo endoscopic assessment of depth of lesion invasiveness. Deeper multi-photon microscopy with autofluorescence imaging of cellular metabolic conditions, whose aspects are tightly related to cellular functioning and to cancer, implemented in tandem with Raman spectroscopy will provide exhaustive characterisation of the examined tissue at morphological, metabolic and molecular levels, allowing in-vivo optical biopsy for bladder cancer diagnosis, grading and staging.
Similar projects All >
Sorted by: Start Date
Project list item
Raman Endoscopic Proteo-lipidomics of Bladder Cancer

European Research Council to Mads SYLVEST BERGHOLT

USD 1,665,219
2019 - 2024
Project list item
Intra-operative MRI-guided Robotic System for Photothermal Therapy of Bladder Cancer

University Grants Committee to Kwok Ka Wai, Wong Kenneth Kin Yip, Vardhanabhuti Varut Vince, TEOH Yuen Chun Jeremy

USD 81,014
2018 - 2021
Project list item
Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

European Commission

USD 6,760,912
2016 - 2020
Project list item
High resolution imaging for early and better detection of bladder cancer

Cancer Prevention and Research Institute of Texas to Rebecca R Richards-Kortum

USD 873,765
2015 -
Project list item
Staging of upper tract urothelial cancer with optical coherence tomography

National Cancer Institute to ANDREW MARTIN ROLLINS, HUI ZHU

USD 548,995
2012 - 2015



    0299 Other Physical Sciences


    0306 Physical Chemistry (incl. Structural)

  • RCDC


  • RCDC





    4.1 Discovery and preclinical testing of markers and technologies

  • Health Research Areas