Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

Geriatric Conditions and Treatment Burden in Older Adults with Non-Muscle-Invasive Bladder Cancer and Their Caregivers

Funder: National Institute on Aging

Funding period
USD 272 K
Funding amount
Abstract
PROJECT SUMMARY/ABSTRACT Treatment burden, defined as ?the work of being a patient and how it impacts patients' functioning and well-being,? is emerging as an important concept that affects quality of life and caregiver well-being in other chronic conditions. Despite the fact that cancer is a burdensome chronic disease, few studies have specifically evaluated treatment burden in cancer. Importantly, cancer is more prevalent in older adults who may already experience high treatment burden from existing geriatric conditions. Compared to younger counterparts, older cancer patients tend to value non-traditional outcomes (e.g. quality of life) and rely on caregivers to coordinate transportation for clinic visits, manage medications, and assist in decision-making. A lack of understanding of the relationships between cancer, aging, treatment burden, and caregiver roles may result in care delivery that is misaligned with the goals of older adults. Non-muscle invasive bladder cancer (NMIBC) is an ideal cancer for studying treatment burden for three reasons: highest median age at diagnosis of all cancer sites; a high recurrence rate necessitating frequent visits for surveillance, bladder instillations, and ambulatory surgery; and a high prevalence of baseline multimorbidity. The objective of this application is to elucidate the relationship between geriatric conditions and treatment burden in older NMIBC patients and their caregivers. The Specific Aims are: 1) Assess the relative contribution of individual geriatric conditions to overall healthcare utilization in the year following NMIBC diagnosis in SEER- Medicare, a nationally representative dataset, 2). Evaluate the associations of specific geriatric conditions and cumulative frailty with patient-reported treatment burden after NMIBC diagnosis in 100 older adults, and 3) Evaluate the associations of patient-reported treatment burden, specific geriatric conditions, and cumulative frailty with caregiver-reported strain in 100 caregivers. This study is innovative because it engages patient and caregiver perspectives to define the new concept of treatment burden within aging and cancer. This study is significant because understanding the relationship between cancer, geriatric conditions, and treatment burden is the critical next step towards redesigning care to reduce the footprint of healthcare work for older cancer patients and caregivers. This GEMSSTAR research project, mentoring committee, and professional development plan will help the PI to become one of the few independent investigators with expertise at the intersection of aging, urologic oncology, and patient-centered outcomes research.
Similar projects All >
Sorted by: Start Date
Project list item
Intravesical delivery of an Fc-enhanced CD40 agonist antibody for the treatment of bladder cancer

Bladder Cancer Advocacy Network to Jeffrey Ravetch, David Knorr

USD 300,000
2020 - 2022
Project list item
Epigenetic regulators of subtype plasticity in bladder cancer

Bladder Cancer Advocacy Network to John Robert Christin

USD 1,700
2020 - 2020
Project list item
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer

National Cancer Institute to NINA BHARDWAJ, JUN ZHU, MATTHEW GALSKY

USD 703,400
2020 - 2025
Project list item
CD40 agonism for the treatment of bladder cancer

National Cancer Institute to CHRISTOPHER STUART GARRIS

USD 64,554
2020 - 2023

System

Categories
  • FOR (ANZSRC)

    1103 Clinical Sciences

  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • FOR (ANZSRC)

    1117 Public Health and Health Services

  • RCDC

    Aging

  • RCDC

    Health Services

  • RCDC

    Rehabilitation

  • RCDC

    Behavioral and Social Science

  • RCDC

    Cancer

  • RCDC

    Clinical Research

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • HRCS RAC

    7.1 Individual care needs

  • Health Research Areas

    Clinical

  • Broad Research Areas

    Clinical Medicine and Science