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Project

[Studies on a novel immunotherapy for bladder cancer by NAD+]

Original in Japanese: Studies on a novel immunotherapy for bladder cancer by NAD+

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.3 M
USD 40 K
Funding amount
Abstract
[At present, no data has been published that examined whether or not NAD + administration was targeted for the therapeutic effect on cancer. In this study, we confirm the antitumor effect of activation of the immune system by NAD + in tumor-bearing mice, and perform immunological analysis thereof. The following three points will be clarified within the research period. -Clarify the anti-tumor effect of NAD + administration on bladder cancer in mice-Clarify the immunological changes during NAD + administration in tumor-bearing mice. -Clarify the potential for clinical application compared with BCG intravesical therapy.]
Original in Japanese
現時点において、NAD+投与の癌に対する治療効果をターゲットとして可否を検討したデータは発表されていない。本研究では、担癌マウスにおいてNAD+による免疫機構の賦活による抗腫瘍効果を確認し、その免疫学的解析を行う。研究期間内に次の3点を明らかにする。・NAD+投与によるマウス膀胱癌に対する抗腫瘍効果を明らかにする・担癌マウスにおけるNAD+投与時の免疫学的変化を明らかにする。・BCG膀胱内注入療法と比較して臨床応用への可能性を明らかする。
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System

Categories
  • FOR (ANZSRC)

    1107 Immunology

  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Immunization

  • RCDC

    Urologic Diseases

  • RCDC

    Vaccine Related

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science