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Project

[Cancer immunotherapy targeting treatment-resistant urothelilal cancer stem cells]

Original in Japanese: Cancer immunotherapy targeting treatment-resistant urothelilal cancer stem cells

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.2 M
USD 38 K
Funding amount
Abstract
[So far, we have established a bladder cancer stem cell clone showing a stable trait in in vitro culture from the bladder cancer cell line UM-UC-3. In this study, we will clarify what kind of antigenic peptides are presented using bladder cancer stem cell line by HLA ligandome analysis. In addition, the effectiveness of immunotherapy targeting bladder cancer stem cells will be evaluated in in vitro and in vivo experimental systems.]
Original in Japanese
我々はこれまで、in vitro 培養で安定した形質を示す膀胱癌幹細胞クローンを膀胱癌細胞株UM-UC-3から樹立した。本研究において、膀胱癌幹細胞株を用いて、どのような抗原ペプチドが提示されているか、HLAリガンドーム解析により明らかとする。また、膀胱癌幹細胞を標的とした免疫療法が有効か、in vitro および in vivo 実験系にて評価する。
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Biotechnology

  • RCDC

    Regenerative Medicine

  • RCDC

    Stem Cell Research

  • RCDC

    Cancer

  • RCDC

    Immunization

  • RCDC

    Stem Cell Research - Nonembryonic - Human

  • RCDC

    Stem Cell Research - Nonembryonic - Non-Human

  • RCDC

    Urologic Diseases

  • RCDC

    Vaccine Related

  • HRCS HC

    Cancer

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science