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Project

[Biomarker screening of urothelial carcinoma using liquid biopsy]

Original in Japanese: Biomarker screening of urothelial carcinoma using liquid biopsy

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.2 M
USD 38 K
Funding amount
Abstract
[Comprehensive solution with liquid biopsy Glycosylation of serum, CTC cell surface glycosylation, quantification of expression of glycosyltransferase and establishment of detection method of glycosyltransferase expression in cfDNA, and malignancy of urothelial cancer using it Separation of CTC and cfDNA from pre- and post-treatment samples of patients diagnosed with urothelial cancer and scheduled to be treated, or regular blood samples of patients with metastatic urothelial cancer, and glucose By monitoring the expression level of chain antigen / glycosyltransferase and the glycosyltransferase copy number in cfDNA, we examine the relationship between pathological malignancy, therapeutic effect of anticancer agents / immunity checkpoint inhibitors, acquisition of therapeutic resistance, and prognosis. To do.]
Original in Japanese
Liquid biopsyによる網羅的解血清糖鎖析、CTC細胞表面糖鎖、糖転移酵素の発現定量およびcfDNA中の糖転移酵素の発現検出法の確立と、それを用いた尿路上皮癌の悪性度・再発・効果予測への有用性を明らかとする.尿路上皮癌と診断され治療予定の患者の治療前後検体、もしくは転移性尿路上皮癌患者の定期採血検体からCTCおよびcfDNAを分離し、糖鎖抗原・糖転移酵素の発現量やcfDNA中の糖転移酵素コピー数をモニタリングし、病理学的悪性度、抗癌剤・免疫チェックポイント阻害剤による治療効果、治療抵抗性獲得や予後との関連を検討する。
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Rare Diseases

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science