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Project

[Novel therapeutic strategy for canine urothelial carcinoma: cancer elimination by anti-inflammation with BRAF inhibitor]

Original in Japanese: Novel therapeutic strategy for canine urothelial carcinoma: cancer elimination by anti-inflammation with BRAF inhibitor

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.3 M
USD 39 K
Funding amount
Abstract
[Canine urothelial cancer (UC) is the only cancer that responds to non-steroidal anti-inflammatory drugs, but lacks resistance development and other treatment options and may be a new treatment to improve prognosis. Established is required. Applicants have shown that UC produces large amounts of prostaglandin E2, which is involved in the promotion of inflammation, and that BRAF gene mutations, which are frequently found in UC, control it. In this study, we believe that targeting this mutation may control the inflammatory environment of UC, and aim to establish a new cancer treatment method using BRAF inhibitors. At the same time, by analyzing the gene expression of UC cells in urine, we would like to clarify the effect of BRAF inhibition on the inflammatory environment in vivo.]
Original in Japanese
イヌ尿路上皮がん(UC)は非ステロイド性抗炎症薬に反応を示す唯一のがんであるが、耐性の発現やその他の治療の選択肢に乏しく、予後の改善のために新たな治療法の確立が求められている。申請者らは、UCが炎症の促進にかかわるプロスタグランジンE2を大量に産生し、UCに高率に認められるBRAF遺伝子変異がそれを制御することを明らかにしてきた。そこで本研究では、この変異を標的にすることでUCの炎症環境を制御できるのではないかと考え、BRAF阻害剤を用いた新たながん治療法の確立を目指す。同時に尿中のUC細胞の遺伝子発現を解析することで、生体におけるBRAF阻害が炎症環境などにもたらす影響を明らかにしたい。
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Biotechnology

  • RCDC

    Cancer

  • RCDC

    Genetics

  • HRCS HC

    Cancer

  • HRCS RAC

    5.1 Pharmaceuticals

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science