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Comparing Two Treatment Options for Recurrent Bladder Cancer

Funder: Patient-Centered Outcomes Research Institute

Funding period
USD 8.5 M
Funding amount
PCORI has identified the need for large studies that look at real-life questions facing diverse patients, caregivers, and clinicians. In 2014, PCORI launched the Pragmatic Clinical Studies initiative to support large-scale comparative effectiveness studies focusing on everyday care for a wide range of patients. The Pragmatic Clinical Studies initiative funded this research project and others. This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.In 2017, more than 58,000 Americans were diagnosed with a type of bladder cancer called non-muscle invasive bladder cancer, or NMIBC. This cancer is limited to the inner layers of the bladder. To treat NMIBC, doctors first remove the tumor, leaving the bladder in place. Then they inject medicine into the bladder.But NMIBC can come back or get worse. If the cancer comes back or worsens, patients have two treatment options:In this study, the research team is comparing patients with NMIBC who get surgery to those who choose medical management. The team is asking patients and their caregivers about their experiences and outcomes following treatment.Results may help doctors, patients, and caregivers considering treatment options for recurrent NMIBC.The research team is enrolling patients with recurrent NMIBC and their caregivers. Patients have chosen either surgery or medical management to treat their cancer.Patients and caregivers are filling out a survey at the start of the study, several times in the first year, and then yearly for up to three years. The survey asks patients and caregivers about their quality of life and also about financial distress and how they feel about their treatment decision. Patients are answering questions about sexual and bladder function, hospital and urology clinic visits, and if they were able to return to work and normal activities. Caregivers are answering questions about the burden of taking care of the patient. The team is looking at patients’ medical records to see if the cancer came back or got worse, and if patients survived.The research team is interviewing 50 patients and 25 caregivers to learn more about their experience with treatment and how they chose surgery or medical management.Patients, caregivers, advocacy organization representatives, guideline developers, and health insurers are helping design the study and choose outcomes important to patients.Engagement Awards Teams Ride Momentum to Research Projects Read a feature story that highlights how three Eugene Washington PCORI Engagement Awards teams clinched additional PCORI funding to channel the lessons and successes of their work into three new research projects -- which includes this study -- that answer patient-centered research questions.
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    1117 Public Health and Health Services

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