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Project

Pluripotent stem cell-derived bladder epithelial progenitors for definitive cell replacement therapy of bladder cancer

Funder: California Institute for Regenerative Medicine

Funding period
EUR 1.3 M
USD 1.4 M
Funding amount
Abstract
Research Objective
We will 1) identify non-invasive bladder cancer patients with (pre)cancerous urothelium by single-cell RNA-seq and 2) replace this dangerous lesion with normal hESC-derived bladder progenitors.
Impact
Replacement of corrupted (pre)cancerous urothelium with pluripotent cell-derived normal bladder progenitors will provide a definitive treatment for bladder cancer, expected to eliminate recurrence.
Major Proposed Activities
To develop a diagnostic surface marker assay to quantify the purity of hPSC-derived human bladder progenitor populations
To use single-cell RNA-seq to determine the purity of hPSC-derived human bladder progenitors and how closely they resemble primary human bladder cells
To test engraftment of primary mouse bladder stem cells, and eventually, hPSC-derived bladder progenitors, in injured mouse bladders
To profile (pre)cancerous bladder cells from patient samples and to develop diagnostic tools to monitor their spread using single-cell RNA-seq
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Regenerative Medicine

  • RCDC

    Stem Cell Research

  • RCDC

    Cancer

  • RCDC

    Stem Cell Research - Embryonic - Human

  • RCDC

    Stem Cell Research - Induced Pluripotent Stem Cell

  • RCDC

    Stem Cell Research - Induced Pluripotent Stem Cell - Human

  • RCDC

    Transplantation

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science