Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

A novel instrument for the analysis of urine for the nonA novel instrument for the analysis of urine for the non-invasive detection of bladder cancer-invasive detection of bladder cancer

Funder: Innovate UK

Funding period
GBP 70 K
USD 90 K
Funding amount
Abstract
Can we detect and monitor bladder cancer with a urine test? For many patients with bladder cancer (BC), their cancer comes back after treatment and so they have to be regularly checked. These patients are checked with a cystoscope. This is a long thin flexible tube with a light and a camera at the end that is inserted into the urethra (the tube that carries urine out of the body) and up into the bladder. The camera shows the inside of the bladder and the doctor can make a diagnosis. This method of diagnosis (cystoscopy) can be uncomfortable for the patient and is expensive to the NHS. This project aims to find out if a new laboratory method could be used instead. The test needs to be able to tell the difference between tumour cells and other things in the urine like regular cells shed into the urine by the normal action of the bladder and germs that are not due to these cancers. To do this we will shine UV and visual light at samples which mimic urine samples and take a video of the samples flowing. We have a new better way of doing this that will give us sharper images of the cells, especially in the UV light, and allow us to look at bigger samples up to 50 ml. Computer software will then take the data from the instrument and tell us information about the cells. We hope to be able to tell the difference between tumour cells, normal cells and blood cells and reduce the number of cystoscopies that patients need in future.
Similar projects All >
Sorted by: Start Date
Project list item
Investigating underlying molecular mechanisms of epigenetic therapies in muscle-invasive bladder cancer

Bladder Cancer Advocacy Network to Swathi Ramakrishnan

USD 1,700
2019 - 2019
Project list item
PFI-TT: The Development of Flow-Through Sensors for the Detection of Bladder Cancer in Urine Samples

Directorate for Engineering to James McGrath, James Roussie

USD 249,435
2019 - 2021
Project list item
Understanding the Burden and Impact of Financial Toxicity in Bladder Cancer: A Mixed Methods Study of 2 Diverse Patient Populations

Bladder Cancer Advocacy Network to Sumeet Kaur Bhanvadia, Siamak Daneshmand, Reginald Tucker-Seeley

USD 50,000
2019 - 2020
Project list item
Recombinant CCL2 as a novel treatment strategy for bladder cancer

Bladder Cancer Advocacy Network to Neelam Mukherjee, Robert Scott Svatek

USD 50,000
2019 - 2020

System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Clinical Research

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • HRCS RAC

    2.1 Biological and endogenous factors

  • HRCS RAC

    4.1 Discovery and preclinical testing of markers and technologies

  • HRCS RAC

    4.2 Evaluation of markers and technologies

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science