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Project

The establishment of new therapeutic strategy for bladder cancer targeting to cancer stem cell

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.2 M
USD 38 K
Funding amount
Abstract
CD44v protein expression was examined immunohistochemically in muscle invasive bladder cancer (MIBC) patients who underwent radical cystectomy. CD44v expression was independently associated with disease recurrence and cancer-specific death in MIBC. Sulfasalazine (SSZ) exerted cytotoxic effects against bladder cancer cells. SSZ in combination with cisplatin (CDDP) appeared to exert strong cytotoxic effects. The inhibitory effects of SSZ with or without CDDP were investigated using murine lung metastatic models. The combination of SSZ with CDDP exerted stronger inhibitory effects on the establishment of lung tumor nodules than SSZ or CDDP alone. The inhibitory effects of SSZ was also investigated using murine orthotopic models. Bladder weight in mice treated with SSZ was significantly lower than that in mice treated with vehicle control.
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Lung Cancer

  • RCDC

    Lung

  • RCDC

    Cancer

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science