Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

Investigation of anti-tumor effect of Axl kinase inhibitor in urothelial carcinoma.

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.8 M
USD 33 K
Funding amount
Abstract
We analyzed Axl-Gas6 signal cascade using both UMUC3 and HT1376 cell lines, which are commercially purchasable UC cell lines. We used Western blotting analysis and immune-staining analysis. HT1376 is weak Axl-staining cell line and UMUC3 is a weak Axl-staining cell line. Commercially purchasable Axl kinase inhibitor, R428, had no cytotoxic ability in itself, but it blocks invasive capacity store-dependently in UMUC3 cell line. The protein expression of Axl and Gas6 by immunohistochemistry and its correlation with clinicopathologic features were investigated in surgical specimens obtained from patients who had been surgically treated for UTUC. Axl protein expression and its ligand Gas6 protein expression associate with each other, and both of them highly associated with worse prognosis of UTUC patients treated by radical nephroureterectomy.
Similar projects All >
Sorted by: Start Date
Project list item
Upper tract urothelial carcinoma is non-basal and T-cell depleted

Bladder Cancer Advocacy Network to Panagiotis Vlachostergios

USD 1,700
2018 - 2018
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
Project list item
Next generation sequencing to enhance initial staging and dynamically monitor disease response in upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Philip Abbosh, Wafik El-Deiry, Elizabeth Plimack

USD 50,000
2018 - 2019
Project list item
Ascertaining the role of mutations in COMPASS-like complex members in the development of upper tract urothelial carcinoma

Bladder Cancer Advocacy Network to Byron H Lee, Nima Sharifi, Ming Hu, Daniel Kim

USD 50,000
2017 - 2018
Project list item
Epithelial to mesenchymal transition thorough GEP100-Arf6-AMAP1 pathway in urothelial cancer

Japan Society for the Promotion of Science to Tatsuaki Daimon

USD 34,348
2015 - 2017

System

Categories
  • FOR (ANZSRC)

    0601 Biochemistry and Cell Biology

  • RCDC

    Cancer

  • RCDC

    Rare Diseases

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science