Please enable JavaScript or talk to your local administrator to get JavaScript enabled.


Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 5.1 M
USD 45 K
Funding amount
The following five results were obtained.1) We found that AXL, which is in the TAM family of receptor tyrosine kinases and its ligand, Gas6 expression were the independent prognostic factors for upper tract urothelial carcinoma. 2) After exposed to nicotine, T24 bladder tumor cell growth was induced through activation of PI3K-Akt-mTOR. NVP-BEZ235 reduced the cell growth by inhibiting the activated PI3K-Akt-mTOR. 3) NVP-BEZ235 inhibited subcutaneous tumor growth and pS6 overexpression induced by nicotine. 4) The combination of cisplatin and NVP-BEZ235 had strong cytotoxic effect. 5) In an orthotopic bladder tumor model, intravesical administration of NVP-BEZ235 had a significant antitumor effect through inhibiting PI3K-Akt-mTOR pathway.
Similar projects All >
Sorted by: Start Date
Project list item
Role of Fgfr2 signaling in bladder injury and regeneration

National Institute of Diabetes and Digestive and Kidney Diseases to CARLTON MATTHEW BATES

USD 234,750
2019 - 2022
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
Project list item
Prevention of Urinary Bladder Cancer with Two Clinically-Ready Agents (Everolimus andNaproxen) When Administered in Combination

National Cancer Institute to CLINTON GRUBBS

USD 709,567
2018 - 2021
Project list item
[Irradiated fibroblast-induced bystander effects on the apoptosis, growth and invasive of urothelial carcinoma under cancer–stromal cell interaction] - Original in Japanese

Japan Society for the Promotion of Science to MAKI NANRI, 昇平 東武, Mitsuru NOGUCHI

USD 40,496
2018 - 2021



    1112 Oncology and Carcinogenesis

  • RCDC


  • RCDC

    Tobacco Smoke and Health

  • RCDC


  • RCDC

    Urologic Diseases



  • Health Research Areas


  • Broad Research Areas

    Basic Science