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Project

Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 5.1 M
USD 45 K
Funding amount
Abstract
The following five results were obtained.1) We found that AXL, which is in the TAM family of receptor tyrosine kinases and its ligand, Gas6 expression were the independent prognostic factors for upper tract urothelial carcinoma. 2) After exposed to nicotine, T24 bladder tumor cell growth was induced through activation of PI3K-Akt-mTOR. NVP-BEZ235 reduced the cell growth by inhibiting the activated PI3K-Akt-mTOR. 3) NVP-BEZ235 inhibited subcutaneous tumor growth and pS6 overexpression induced by nicotine. 4) The combination of cisplatin and NVP-BEZ235 had strong cytotoxic effect. 5) In an orthotopic bladder tumor model, intravesical administration of NVP-BEZ235 had a significant antitumor effect through inhibiting PI3K-Akt-mTOR pathway.
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Tobacco

  • RCDC

    Tobacco Smoke and Health

  • RCDC

    Cancer

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science