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Project

New therapeutic strategy targeting CD44 against urothelial cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.2 M
USD 40 K
Funding amount
Abstract
We examined the immunohistochemical experession of CD44v in urothelial cancer (UC) and analyzed its clinical significance in patients treated with nephroureterectomy for invasive UC. Multivariate analysis showed that CD44v expression was the independent risk factors for cancer-specific mortality. Metformin markedly reduced the viability of the highly CD44v-expressing T24 cells in a dose-dependent manner.Cell growth inhibition was significantly higher in the combination therapy compared to metformin or cisplatin alone in T24 cells. Flow cytometry revealed that metformin selectively reduced the proportion of highly CD44v-expressing tumor cells. Combination therapy showed marked suppression of tumor growth compared with control, and metformin and CDDP monotherapy groups in xenograft model.
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science