Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

NVP-BEZ235 Therapy for Bladder Cancer and Prevention of Tumor Invasion and Metastasis

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.0 M
USD 39 K
Funding amount
Abstract
NVP-BEZ235 inhibited the viability of MBT-2 cells in a dose-dependent manner. Furthermore, the expression of pAkt, pS6, and p4EBP1 was inhibited in NVP-BEZ235-treated MBT-2 cells. Orthotopic models were established by implanting MBT-2 cells into the bladders of female C3H/He mice. Bladder weights were significantly lower in the NVP-BEZ235-treated group than in the control group (P < 0.05). An analysis of the tumor tissues revealed that the NVP-BEZ235 treatment strongly reduced pAkt, pS6, and p4EBP1 levels. An immunohistochemical analysis showed that NVP-BEZ235 significantly inhibited the expression of pS6. Intravesically administered NVP-BEZ235 exerted significant antitumor effects in the orthotopic bladder cancer model by inhibiting the PI3K/AKT/mTOR pathway. The intravesical instillation of a dual PI3K/mTORC1/2 inhibitor may represent a novel therapy for the treatment of bladder cancer.
Similar projects All >
Sorted by: Start Date
Project list item
Regulatory T cells in intravesical BCG therapy for non-muscle invasive bladder cancer

Japan Society for the Promotion of Science to Mitsuhiro NARITA, Kazumasa OGASAWARA, 亮介 村井, Akihiro KAWAUCHI, Tatsuhiro YOSHIKI, Susumu KAGEYAMA, Eiki Hanada

USD 45,237
2014 - 2017
Project list item
Smoking induces tumor aggressiveness and acquiring chemoresistance in bladder cancer.

Japan Society for the Promotion of Science to Kazuyuki Yuge

USD 34,407
2014 - 2016
Project list item
Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer

Japan Society for the Promotion of Science to Eiji KIKUCHI, TAKEO KOSAKA, Akira MIYAJIMA

USD 45,237
2014 - 2017
Project list item
Badder instillation treatment of periostin in a mouse orthotopic model of bladder cancer

Japan Society for the Promotion of Science to Chul Jang KIM, Hirokazu INOUE

USD 45,598
2013 - 2016

System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science