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The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.2 M
USD 46 K
Funding amount
Using a multi-institutional and retrospective cohort of patients with upper tract urothelial carcinoma (UTUC) in Japan, we found that the absence of renin-angiotensin system (RAS) inhibitors was significantly associated with disease recurrence following radical nephroureterectomy independent of other clinicopathological parameter, suggesting RAS inhibition might be effective to prevent subsequent relapsing in UTUC. Moreover, immunohistochemical analysis in surgical specimens revealed that the microvessel density in tumors was significantly associated with oncological outcome in UTUC patients, suggesting the importance of its upper modulator of RAS regulation in UTUC.
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