Please enable JavaScript or talk to your local administrator to get JavaScript enabled.


Investigation of Mechanism of Action of Steroid Sulfatase in Bladder Cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 5.3 M
USD 55 K
Funding amount
we found out that steroid sulfatase (STS), an enzyme involved in androgen synthesis, is an important factor of invasion and prognosis of bladder cancer (BCa) patients. First, we demonstrated that the expression level of STS was significantly higher in muscle invasive BCa compared to non muscle-invasive BCa and the prognosis of STS positive Bca is significantly worse than that of STS negative BCa. Sedond, STS-knock down BCa cells showed less migration and invasion capability. Lastly, we showed that STS is relevant to epithelial to mesenchymal factors such as vimentin and ZEB1.In conclusion, we showed the possibility that STS is a novel target of BCa treatment.
Similar projects All >
Sorted by: Start Date
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
Project list item
Novel Biomarkers for the Clinical Management of Bladder Cancer

National Cancer Institute to VINATA B LOKESHWAR

USD 902,622
2018 - 2023
Project list item
Subtyping Bladder Cancer: A Multi-omic, Exposure-informed, Genealogical Approach (MErGE)

National Cancer Institute to HEIDI ANNE HANSON

USD 298,810
2018 - 2023
Project list item
New Drug and Technology Assessment in Bladder Cancer: Creation of a Novel Canadian Policy Model for Bladder Cancer

Canadian Institutes of Health Research to Murray Dale Krahn, Girish Satish Kulkarni, William Wai Lun Wong, George Andrew Tomlinson, Nathan Perlis, Wassim Kassouf, Peter Colin Black, Shabbir Muhammad Husayn Alibhai

USD 77,161
2018 - 2019



    1112 Oncology and Carcinogenesis

  • RCDC


  • RCDC

    Urologic Diseases




    2.1 Biological and endogenous factors

  • Health Research Areas


  • Broad Research Areas

    Clinical Medicine and Science