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Risk group stratification to predict prognosis in Japanese patients with urothelial carcinoma

Funder: Japan Society for the Promotion of Science

Funding period
JPY 5.1 M
USD 53 K
Funding amount
Combined ERCC1 and XRCC1 expression may serve as an independent prognostic marker for survival in bladder cancer patients receiving combined trimodality therapy. Prospective studies with a larger sample size are required to confirm these results.Risk group stratification based on preoperative clinical T stage, voided urine cytology, and WBC counts may be useful for selection of UUT-UC patients for neoadjuvant chemotherapy. Prospective studies with larger numbers of patients and a longer follow-up period are needed to confirm our results.UTUC with variant histology might be a phenotype of high-grade, locally aggressive advanced tumors rather than of systemic disease. Variant histology may be useful for selection of patients with pT3 and more invasive UTUC for adjuvant therapy. Prospective studies in a larger number of patients with a centralized pathological review are needed to confirm our results.
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    1112 Oncology and Carcinogenesis

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    Clinical Research

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    Rare Diseases

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    Clinical Medicine and Science