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Analysis of Heparanase for invasion abilities of bladder cancer cells

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.6 M
USD 33 K
Funding amount
Heparan sulfate proteoglycan syndecan-1, CD138, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. We previously reported that syndecan-1(CD138) might contribute to urothelial carcinoma cell survival and progression. In the present study, we focused on the role of “Heparanase” that was enzyme activated syndecan-1 in human urothelial carcinoma of the urinarybladder.Heparanase induced ability of invasion and autophagy in urothelial carcinoma. Downregulation of heparanase induced apoptosis. Heparanase might contribute to urothelial carcinoma cell survival and inbasion.
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    0601 Biochemistry and Cell Biology


    1112 Oncology and Carcinogenesis

  • RCDC


  • RCDC

    Rare Diseases

  • RCDC

    Urologic Diseases




    2.1 Biological and endogenous factors

  • Health Research Areas


  • Broad Research Areas

    Basic Science