Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

Analysis of Heparanase for invasion abilities of bladder cancer cells

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.6 M
USD 33 K
Funding amount
Abstract
Heparan sulfate proteoglycan syndecan-1, CD138, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. We previously reported that syndecan-1(CD138) might contribute to urothelial carcinoma cell survival and progression. In the present study, we focused on the role of “Heparanase” that was enzyme activated syndecan-1 in human urothelial carcinoma of the urinarybladder.Heparanase induced ability of invasion and autophagy in urothelial carcinoma. Downregulation of heparanase induced apoptosis. Heparanase might contribute to urothelial carcinoma cell survival and inbasion.
Similar projects All >
Sorted by: Start Date
Project list item
Characterization of Nectin-4 expression in molecular subtypes of urothelial cancer and mechanisms of resistance to enfortumab vedotin

Bladder Cancer Advocacy Network to Carissa Ellen Chu

USD 1,700
2020 - 2020
Project list item
Effect of APOBEC3 on Bladder Cancer Biology and Response to Immunotherapy

National Cancer Institute to ANDREW TRUONG

USD 45,016
2020 - 2023
Project list item
Roles of epigenetic regulators in bladder cancer progression

University of California - Cancer Research Coordinating Committee to Zhu Wang

USD 74,960
2020 - 2020
Project list item
Analysis of the antineoplastic action of Class I HDAC inhibitors to define new combination therapies for urothelial carcinoma

German Research Foundation to Günter Niegisch, Michèle Janine Hoffmann

 
2020 -

System

Categories
  • FOR (ANZSRC)

    0601 Biochemistry and Cell Biology

  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Rare Diseases

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science