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Project

The role of regulatory T cell and related chemokines in urothelial carcinoma of the bladder

Funder: Japan Society for the Promotion of Science

Funding period
JPY 2.9 M
USD 26 K
Funding amount
Abstract
The aim of this project is to evaluate the association between topical immunostatus/systemic inflammation and the risk of BCG refractory non-muscle invasive disease and metastatic muscle invasive disease. The immunohistochemical staining analysis of tumor tissue specimes with FOXP3 (Treg maker) and CD204 (TAM marker) antibodies revealed that high counts of Treg and TAM were associated with shorter recurrence-free survival and disease-free survival. The time-couse analysis of urine obtained from patients treated with intravesical BCG demonstarted that the expression of T cell makers including FOXP3 was increased with time. On the otherhand, B cell-related antigens showed much less chage compared to T cell-related antigens. We will accumulate the patients number.
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Urologic Diseases

  • HRCS HC

    Inflammatory and Immune System

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science