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Development of novel diagnostic procedure for detection of upper urinary tract urothelial cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.7 M
USD 42 K
Funding amount
We hypothesized that a fraction of upper urinary tract urothelial carcinoma (UTUC) cases in Japan might result from past intake of aristolochic acid (AA), a powerful nephrotoxin and human carcinogen, which cause UTUC. In contrast to the high incidence of AA-associated UTUC in Taiwan cohort, our study indicated that confirmed AA-exposure in Japanese UTUC patients were rare.We examined the efficacy of activated protein kinase X in urine sample to detect urothelial cancer. We found the high sensitivity and specificity of this assay, and suggested the activated protein kinase X as promising biomarker for detecting urothelial cancer.
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    1004 Medical Biotechnology

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    Clinical Research

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    Urologic Diseases



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    Clinical Medicine and Science