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Development of a sensitive epigenomic biomarker for urothelial cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.6 M
USD 32 K
Funding amount
It is now apparent that BCa is a genetic and epigenetic disease, and that aberrant methylation of a number of tumor-related genes is involved in BCa. Moreover, several studies have shown that urinary DNA methylation may be a useful marker for BCa diagnosis. MicroRNAs (miRNAs), which are small noncoding RNAs that post-transcriptionally regulate gene expression, have also been strongly implicated in BCa. We identified a set of miRNA genes whose promoter CpG islands are prevalently hypermethylated in BCa cells. We prospectively collected self-voided urine samples from non-muscle invasive BCa (NMIBC) who had undergone transurethral resection of BCa. We found that the number of methylated genes (M-score) and quantitative levels of methylation in the urine specimens are strongly associated with current and late intravesical recurrence of BCa. Our data suggest that urinary methylation of miRNA genes may be a useful marker for detecting and predicting BCa recurrence.
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    0604 Genetics

  • RCDC


  • RCDC

    Human Genome

  • RCDC


  • RCDC


  • RCDC

    Urologic Diseases



  • Health Research Areas


  • Broad Research Areas

    Basic Science