Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

Development of a sensitive epigenomic biomarker for urothelial cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 3.6 M
USD 32 K
Funding amount
Abstract
It is now apparent that BCa is a genetic and epigenetic disease, and that aberrant methylation of a number of tumor-related genes is involved in BCa. Moreover, several studies have shown that urinary DNA methylation may be a useful marker for BCa diagnosis. MicroRNAs (miRNAs), which are small noncoding RNAs that post-transcriptionally regulate gene expression, have also been strongly implicated in BCa. We identified a set of miRNA genes whose promoter CpG islands are prevalently hypermethylated in BCa cells. We prospectively collected self-voided urine samples from non-muscle invasive BCa (NMIBC) who had undergone transurethral resection of BCa. We found that the number of methylated genes (M-score) and quantitative levels of methylation in the urine specimens are strongly associated with current and late intravesical recurrence of BCa. Our data suggest that urinary methylation of miRNA genes may be a useful marker for detecting and predicting BCa recurrence.
Similar projects All >
Sorted by: Start Date
Project list item
Urinary microbiota characterization of superficial bladder Cancer patients undergoing BCG immunotherapy

São Paulo Research Foundation to Anamaria Aranha Camargo

 
2018 - 2022
Project list item
Targeting TAM (Tyro3-Axl-Mer) family of transmembrane receptor tyrosine kinases in bladder cancer.

Bladder Cancer Advocacy Network to Arpita Roy

USD 1,700
2018 - 2018
Project list item
Novel Biomarkers for the Clinical Management of Bladder Cancer

National Cancer Institute to VINATA B LOKESHWAR

USD 902,622
2018 - 2023
Project list item
Subtyping Bladder Cancer: A Multi-omic, Exposure-informed, Genealogical Approach (MErGE)

National Cancer Institute to HEIDI ANNE HANSON

USD 298,810
2018 - 2023

System

Categories
  • FOR (ANZSRC)

    0604 Genetics

  • RCDC

    Biotechnology

  • RCDC

    Human Genome

  • RCDC

    Cancer

  • RCDC

    Genetics

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science