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Project

Investigation on usefulness of Fes / Fer as new therapeutic target and predictive factor in urothelial cancer

Funder: Japan Society for the Promotion of Science

Funding period
JPY 4.8 M
USD 43 K
Funding amount
Abstract
In T24 cell which is urothelial cancer (UC) cell with high malignant potential, Fes knock-down (KD) lead to significantly suppression of cancer cell proliferation, invasion and migration (P = 0.003, 0.018, and <0.001, respectively). Such significant change by Fes-KD was not detected in 5637 and RT4 cell. In 2013 bladder cancer (BC) patients, there was no significant relationship between Fes expression and muscle invasive status. However, in patients with high grade cancer, Fes expression in muscle invasive BC (MIBC) was significantly higher (P = 0.002) than that in non-MIBC (NMIBC), and its was positively correlated to cell proliferation (P = 0.002). In addition, Fes expression was significantly associated with metastasis-free survival in high grade BC (P = 0.021). On the other hand, class III beta-tubulin (TUBB3), which is Fes/Fer-related molecule, was useful predictor for anti-cancer effects of second-line paclitaxel-based chemotherapy for patients with cisplatin-resistant UC.
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System

Categories
  • FOR (ANZSRC)

    1112 Oncology and Carcinogenesis

  • RCDC

    Cancer

  • RCDC

    Urologic Diseases

  • HRCS HC

    Cancer

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Clinical Medicine and Science